{"slug":"epigenetic","tag":"epigenetic","variants":["epigenetic"],"description":"No description yet","count":4,"kinds":{"target":4},"related":[{"slug":"driver","tag":"driver","shared":1}],"records":[{"id":"idh","kind":"target","name":"IDH1 / IDH2","route":"/targets/idh/","tldr":"A metabolic enzyme whose mutant form produces a molecule that scrambles how genes are read; blocking it slows brain tumours and leukaemias."},{"id":"menin","kind":"target","name":"Menin","route":"/targets/menin/","tldr":"A scaffold protein that certain leukaemias need to keep their genes switched on; the first drug against it was approved in 2024."},{"id":"ezh2","kind":"target","name":"EZH2","route":"/targets/ezh2/","tldr":"EZH2 is an enzyme that silences genes. The first drug against it treated a rare sarcoma and some lymphomas until it was withdrawn in 2026 for causing second blood cancers."},{"id":"hdac","kind":"target","name":"Histone deacetylases (HDAC)","route":"/targets/hdac/","tldr":"Histone deacetylases tighten the packaging of DNA so that genes are switched off. Drugs that block them loosen the packaging and can wake up genes that make lymphoma cells stop growing or die."}]}