{"slug":"irae","tag":"irae","variants":["irae"],"description":"No description yet","count":1,"kinds":{"technology":1},"related":[{"slug":"late-effects","tag":"late-effects","shared":1},{"slug":"rejuvenation","tag":"rejuvenation","shared":1},{"slug":"survivorship","tag":"survivorship","shared":1}],"records":[{"id":"rejuv-recovery-endocrine-permanence","kind":"technology","name":"Immune endocrine damage is usually permanent, and almost nobody is told","route":"/technologies/rejuv-recovery-endocrine-permanence/","status":"established","tldr":"Most immune side effects of checkpoint inhibitors settle. The hormone glands are the exception: a pituitary, thyroid, adrenal or insulin-making gland destroyed by the immune system does not grow back, and the replacement treatment that follows is usually for life. In the follow-up cohorts 83 per cent of hormone problems were still present three months after the drug stopped."}]}