{"slug":"landmark-watch","tag":"landmark-watch","variants":["landmark-watch"],"description":"No description yet","count":1,"kinds":{"paper":1},"related":[{"slug":"interception","tag":"interception","shared":1},{"slug":"regulatory-t-cells","tag":"regulatory-t-cells","shared":1}],"records":[{"id":"paper-gamble-preinvasive-treg-axis-lung-cancer-interception-nature-2026","kind":"paper","name":"A preinvasive regulatory T cell axis for lung cancer interception","route":"/key-papers/paper-gamble-preinvasive-treg-axis-lung-cancer-interception-nature-2026/","tldr":"Before lung cancer becomes invasive, a family of immune-dampening cells (effector regulatory T cells) builds up in the precancerous airway lining and in the blood, and rising levels marked people whose early cancers grew fast. In mice, blocking the PI3K-delta signal these cells depend on reduced lung tumours."}]}