{"slug":"methylation","tag":"methylation","variants":["methylation"],"description":"No description yet","count":1,"kinds":{"biomarker":1},"related":[{"slug":"biomarker","tag":"biomarker","shared":1},{"slug":"no-approval","tag":"no-approval","shared":1}],"records":[{"id":"mgmt-promoter-methylation","kind":"biomarker","name":"MGMT promoter methylation","route":"/biomarkers/mgmt-promoter-methylation/","tldr":"Methylation of the MGMT promoter switches off the repair enzyme that undoes temozolomide's damage. Methylated glioblastomas live longer on temozolomide; unmethylated ones gain little, and trials now use the result to spare or intensify chemotherapy."}]}