{"slug":"protein-design","tag":"protein-design","variants":["protein-design"],"description":"No description yet","count":10,"kinds":{"person":1,"institution":1,"company":5,"technology":3},"related":[{"slug":"ai","tag":"ai","shared":6},{"slug":"foundation-model","tag":"foundation-model","shared":3},{"slug":"clinician-scientist","tag":"clinician-scientist","shared":1},{"slug":"drug-discovery","tag":"drug-discovery","shared":1},{"slug":"leadership","tag":"leadership","shared":1}],"records":[{"id":"david-baker","kind":"person","name":"David Baker","route":"/people/david-baker/","tldr":"Nobel laureate biochemist who founded and directs the Institute for Protein Design, which builds new proteins for medicine including cancer therapeutics."},{"id":"institute-for-protein-design","kind":"institution","name":"Institute for Protein Design (University of Washington)","route":"/institutions/institute-for-protein-design/","tldr":"David Baker's institute, where de novo protein design and the RFdiffusion models come from (Nobel Prize in Chemistry 2024)."},{"id":"evolutionaryscale","kind":"company","name":"EvolutionaryScale","route":"/companies/evolutionaryscale/","tldr":"Spun out of Meta's protein team; makes the ESM3 protein language model that generated a new fluorescent protein."},{"id":"chai-discovery","kind":"company","name":"Chai Discovery","route":"/companies/chai-discovery/","tldr":"Makes Chai-1 and Chai-2, open-weight structure models used for antibody and binder design."},{"id":"cradle-bio","kind":"company","name":"Cradle","route":"/companies/cradle-bio/","tldr":"Cradle is a protein-engineering AI platform used by pharma to optimise antibodies and enzymes."},{"id":"profluent-bio","kind":"company","name":"Profluent","route":"/companies/profluent-bio/","tldr":"Profluent uses protein language models to design new gene editors (OpenCRISPR-1) and antibodies."},{"id":"latent-labs","kind":"company","name":"Latent Labs","route":"/companies/latent-labs/","tldr":"Founded by an AlphaFold co-developer to make protein design programmable; released Latent-X in 2025."},{"id":"chai-1","kind":"technology","name":"Chai-1 / Chai-2","route":"/technologies/chai-1/","status":"emerging","tldr":"Structure and antibody-design models from Chai Discovery, with Chai-2 reporting high zero-shot antibody hit rates."},{"id":"esm3","kind":"technology","name":"ESM3 (EvolutionaryScale)","route":"/technologies/esm3/","status":"emerging","tldr":"ESM3 is a generative protein model that designed a working fluorescent protein far from any natural sequence."},{"id":"rfdiffusion","kind":"technology","name":"RFdiffusion / RFdiffusion2 and ProteinMPNN (Baker Lab)","route":"/technologies/rfdiffusion/","status":"emerging","tldr":"The tools that design entirely new proteins to bind a chosen target, now used for cancer binders and antibodies."}]}