{"slug":"scientist","tag":"scientist","variants":["scientist"],"description":"No description yet","count":7,"kinds":{"person":7},"related":[{"slug":"cancer-biology","tag":"cancer-biology","shared":4},{"slug":"nobel-laureate","tag":"nobel-laureate","shared":2},{"slug":"cell-therapy","tag":"cell-therapy","shared":1},{"slug":"drug-delivery","tag":"drug-delivery","shared":1},{"slug":"genomics","tag":"genomics","shared":1},{"slug":"immunology","tag":"immunology","shared":1}],"records":[{"id":"yardena-samuels","kind":"person","name":"Yardena Samuels","route":"/people/yardena-samuels/","tldr":"She found that PIK3CA is one of the most frequently mutated genes in human cancer, then spent the next twenty years working out which of a melanoma's mutations the immune system can actually see."},{"id":"yosef-yarden","kind":"person","name":"Yosef Yarden","route":"/people/yosef-yarden/","tldr":"One of the people who worked out what the HER family of receptors does and how antibodies against them behave, including why combining two antibodies against the same receptor works better than either alone."},{"id":"moshe-oren","kind":"person","name":"Moshe Oren","route":"/people/moshe-oren/","tldr":"Cloned p53 and then spent a career on what it does. The field's first reading of his own 1984 result, that p53 was an oncogene, turned out to be wrong, and the correction is the better story."},{"id":"aaron-ciechanover","kind":"person","name":"Aaron Ciechanover","route":"/people/aaron-ciechanover/","tldr":"Shared the 2004 Nobel Prize in Chemistry for discovering how cells label proteins for destruction. That labelling system is what proteasome inhibitors block and what every protein degrader hijacks."},{"id":"avram-hershko","kind":"person","name":"Avram Hershko","route":"/people/avram-hershko/","tldr":"Shared the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation, and still works on how the machinery that destroys proteins controls cell division."},{"id":"yechezkel-barenholz","kind":"person","name":"Yechezkel Barenholz","route":"/people/yechezkel-barenholz/","tldr":"Invented the chemistry that made Doxil work, the first nanomedicine any regulator approved, which is still a standard treatment for relapsed ovarian cancer three decades later."},{"id":"michal-besser","kind":"person","name":"Michal Besser","route":"/people/michal-besser/","tldr":"Runs the laboratory that actually grows the cells. Her papers are the reason anyone outside the United States believed a hospital could manufacture tumour-infiltrating lymphocytes reliably."}]}