{"slug":"supporting","tag":"supporting","variants":["supporting"],"description":"Technologies and companies that keep treatment running rather than treat directly: manufacturing, supply, logistics and tooling.","count":147,"kinds":{"technology":50,"company":97},"related":[],"records":[{"id":"closed-automated-cell-manufacturing","kind":"technology","name":"Closed automated cell-therapy manufacturing","route":"/technologies/closed-automated-cell-manufacturing/","status":"established","tldr":"Sealed, robot-run machines that turn a patient's blood cells into a CAR-T product with far fewer hands, clean rooms, and mistakes."},{"id":"point-of-care-cell-manufacturing","kind":"technology","name":"Point-of-care and decentralised cell manufacturing","route":"/technologies/point-of-care-cell-manufacturing/","status":"emerging","tldr":"Making CAR-T cells at or near the hospital instead of shipping cells to a central factory and back."},{"id":"viral-vector-manufacturing","kind":"technology","name":"Viral vector manufacturing (lentiviral, retroviral, AAV)","route":"/technologies/viral-vector-manufacturing/","status":"established","tldr":"Producing the engineered viruses that carry a CAR gene into T cells. Viral vector manufacturing is a long-standing bottleneck for cell and gene therapy."},{"id":"plasmid-dna-manufacturing","kind":"technology","name":"Plasmid DNA and mRNA raw-material manufacturing","route":"/technologies/plasmid-dna-manufacturing/","status":"established","tldr":"Plasmid DNA and mRNA raw materials are the DNA templates and enzymes behind viral vectors and mRNA vaccines. They are invisible to patients but decisive for supply."},{"id":"adc-cdmo-manufacturing","kind":"technology","name":"ADC bioconjugation manufacturing (CDMOs)","route":"/technologies/adc-cdmo-manufacturing/","status":"established","tldr":"ADC bioconjugation manufacturing joins a payload so toxic it needs the top containment class (OEB 5) to an antibody, then checks drug-to-antibody ratio and free payload. Capacity sits with a handful of contractors such as Lonza, WuXi XDC and Samsung Biologics, so long queues and China-based exposure shape who can develop ADCs."},{"id":"radiopharmacy-network","kind":"technology","name":"Radiopharmacy and cyclotron networks","route":"/technologies/radiopharmacy-network/","status":"standard-of-care","tldr":"The factories and courier routes that make and deliver short-lived radioactive tracers to hospitals within hours."},{"id":"therapy-isotope-supply-chain","kind":"technology","name":"Therapeutic isotope supply chain (Mo-99, Lu-177, Ac-225)","route":"/technologies/therapy-isotope-supply-chain/","status":"established","tldr":"Where the radioactive atoms for imaging and therapy actually come from: ageing reactors, new accelerators, and a scramble for actinium."},{"id":"long-read-sequencing","kind":"technology","name":"Long-read sequencing (PacBio, Oxford Nanopore)","route":"/technologies/long-read-sequencing/","status":"established","tldr":"Long-read sequencing (PacBio HiFi, Oxford Nanopore) reads single DNA molecules in stretches of thousands of bases, so rearrangements, repeat expansions, gene fusions and methylation appear in one run where short-read machines miss them. Nanopore can classify a brain tumour during surgery in under an hour; throughput per dollar still trails the largest short-read instruments."},{"id":"next-gen-short-read-platforms","kind":"technology","name":"New short-read sequencing platforms","route":"/technologies/next-gen-short-read-platforms/","status":"emerging","tldr":"New short-read sequencing platforms from Ultima Genomics, Element Biosciences, Roche and MGI compete with Illumina by cutting the cost per gigabase, with Ultima claiming a genome under 100 dollars. Cheaper reads make whole-genome tumour-normal sequencing and deep ctDNA testing affordable in principle, but clinical assays must be revalidated and Illumina's installed base still dominates."},{"id":"spatial-biology-instruments","kind":"technology","name":"Spatial biology instruments","route":"/technologies/spatial-biology-instruments/","status":"emerging","tldr":"Spatial biology instruments are machines that map which genes and proteins are active in each part of a tumour slice."},{"id":"whole-slide-scanners","kind":"technology","name":"Whole-slide scanners and image management","route":"/technologies/whole-slide-scanners/","status":"established","tldr":"The scanners that turn glass slides into gigapixel images, and the software that stores and serves them, without which pathology AI cannot run."},{"id":"treatment-planning-systems","kind":"technology","name":"Radiotherapy treatment planning and QA software","route":"/technologies/treatment-planning-systems/","status":"standard-of-care","tldr":"The software that calculates exactly how radiation beams should be shaped and checks the machine delivered it."},{"id":"auto-contouring-ai","kind":"technology","name":"AI auto-contouring and adaptive planning","route":"/technologies/auto-contouring-ai/","status":"established","tldr":"Software that draws organs and tumours on scans automatically, saving hours per patient and making daily plan adaptation practical."},{"id":"oncology-real-world-data","kind":"technology","name":"Oncology EHR and real-world data platforms","route":"/technologies/oncology-real-world-data/","status":"established","tldr":"Databases built from millions of real patient records, used to see how treatments work outside trials and to run studies without new trials."},{"id":"clinical-trial-software","kind":"technology","name":"Clinical trial software (EDC, eCOA, CTMS, RTSM)","route":"/technologies/clinical-trial-software/","status":"standard-of-care","tldr":"Clinical trial software is the set of systems that collect trial data, randomise patients, and keep every form auditable."},{"id":"decentralised-clinical-trials","kind":"technology","name":"Decentralised and hybrid clinical trials","route":"/technologies/decentralised-clinical-trials/","status":"established","tldr":"Running parts of a trial at home or locally, with telehealth, home nursing, and remote monitoring, so patients far from big centres can take part."},{"id":"community-oncology-networks","kind":"technology","name":"Community oncology and site networks","route":"/technologies/community-oncology-networks/","status":"standard-of-care","tldr":"The clinics where most cancer patients are actually treated, increasingly organised into large networks that also run trials."},{"id":"contract-research-organisations","kind":"technology","name":"Contract research organisations (CROs)","route":"/technologies/contract-research-organisations/","status":"standard-of-care","tldr":"Companies that run clinical trials for sponsors: sites, monitoring, data, and regulatory filing."},{"id":"imaging-core-labs","kind":"technology","name":"Imaging core labs and central review","route":"/technologies/imaging-core-labs/","status":"standard-of-care","tldr":"Independent radiologists who re-read every scan in a trial the same way, so response rates mean the same thing across hospitals."},{"id":"biobanking","kind":"technology","name":"Biobanking and tissue procurement","route":"/technologies/biobanking/","status":"established","tldr":"Freezers full of consented tumour samples with matched clinical data, which every biomarker and drug programme depends on."},{"id":"reference-laboratories","kind":"technology","name":"Reference laboratories and companion-diagnostic testing","route":"/technologies/reference-laboratories/","status":"standard-of-care","tldr":"The big labs that run most biomarker tests, and the reagent makers whose stains decide who gets a drug."},{"id":"pet-tracer-manufacturing","kind":"technology","name":"PET tracer manufacturing and distribution","route":"/technologies/pet-tracer-manufacturing/","status":"standard-of-care","tldr":"Making PSMA, FDG, and new tracers under drug-manufacturing rules and delivering them daily."},{"id":"nuclear-medicine-hardware","kind":"technology","name":"Nuclear medicine and total-body PET hardware","route":"/technologies/nuclear-medicine-hardware/","status":"established","tldr":"Nuclear medicine hardware means the scanners themselves: PET/CT, SPECT/CT, and new total-body PET that images the whole body at once."},{"id":"remote-patient-monitoring","kind":"technology","name":"Electronic patient-reported outcomes and remote monitoring","route":"/technologies/remote-patient-monitoring/","status":"established","tldr":"Apps and sensors that let patients report symptoms between visits, which in trials improved survival and cut emergency visits."},{"id":"pharmacy-automation","kind":"technology","name":"Oncology pharmacy automation and compounding robots","route":"/technologies/pharmacy-automation/","status":"established","tldr":"Robots and closed systems that prepare chemotherapy doses safely, protecting pharmacists from hazardous drugs and patients from errors."},{"id":"ai-compute-platforms","kind":"technology","name":"AI compute and model platforms for oncology","route":"/technologies/ai-compute-platforms/","status":"emerging","tldr":"AI compute platforms are the GPUs, model libraries, and cloud services that pathology, radiology, and drug-design AI run on."},{"id":"sterile-fill-finish","kind":"technology","name":"Sterile fill-finish and lyophilisation","route":"/technologies/sterile-fill-finish/","status":"standard-of-care","tldr":"Sterile fill-finish is putting the finished drug into vials under sterile conditions. It is a frequent cause of shortages when capacity is tight."},{"id":"generic-drug-shortage-response","kind":"technology","name":"Generic oncology drug supply and shortage mitigation","route":"/technologies/generic-drug-shortage-response/","status":"established","tldr":"Keeping cheap, essential chemotherapy drugs like cisplatin available; shortages in 2023 forced rationing in US hospitals."},{"id":"hospital-information-systems-oncology","kind":"technology","name":"Oncology EHR modules and treatment pathways","route":"/technologies/hospital-information-systems-oncology/","status":"standard-of-care","tldr":"The ordering and record systems oncologists use every day, including built-in treatment pathways that steer drug choice."},{"id":"high-potency-payload-synthesis","kind":"technology","name":"Payload-linker synthesis (high-potency API)","route":"/technologies/high-potency-payload-synthesis/","status":"established","tldr":"Payload-linker synthesis makes the cytotoxic small molecules inside ADCs (exatecan, MMAE, DM1, PBD dimers), whose occupational exposure limits sit in the nanogram range, in facilities built so a speck of dust cannot harm a worker. A handful of licensed sites such as Lonza and WuXi STA supply them, and their lead times gate hundreds of ADCs in development."},{"id":"apheresis-starting-material","kind":"technology","name":"Apheresis and starting-material collection","route":"/technologies/apheresis-starting-material/","status":"standard-of-care","tldr":"Apheresis is collecting a patient's white blood cells through a machine over several hours. Every autologous CAR-T begins here, and the quality of these cells shapes the final product."},{"id":"cell-therapy-cold-chain","kind":"technology","name":"Cryopreservation and cell-therapy cold chain","route":"/technologies/cell-therapy-cold-chain/","status":"established","tldr":"Freezing cells at minus 150 degrees and shipping them in liquid-nitrogen 'dry shippers' with tracking, so a living drug arrives alive and matched to the right patient."},{"id":"cell-therapy-orchestration-software","kind":"technology","name":"Cell-therapy orchestration and chain-of-identity software","route":"/technologies/cell-therapy-orchestration-software/","status":"established","tldr":"Scheduling and tracking software that makes sure each patient's cells come back to that patient, on time."},{"id":"cell-therapy-release-testing","kind":"technology","name":"Cell-therapy release and potency testing","route":"/technologies/cell-therapy-release-testing/","status":"established","tldr":"The quality checks a CAR-T batch must pass before it can be given: sterile, correct identity, enough live CAR-positive cells, and no replicating virus."},{"id":"allogeneic-cell-banking","kind":"technology","name":"Allogeneic donor and iPSC master cell banks","route":"/technologies/allogeneic-cell-banking/","status":"emerging","tldr":"Making cell therapies from a healthy donor or stem-cell line in advance, so patients get an off-the-shelf product instead of waiting weeks."},{"id":"monoclonal-antibody-manufacturing","kind":"technology","name":"Antibody manufacturing (CHO bioprocessing)","route":"/technologies/monoclonal-antibody-manufacturing/","status":"standard-of-care","tldr":"Antibody manufacturing means growing antibody drugs like pembrolizumab or trastuzumab in vats of engineered hamster cells, then purifying them. It is the industrial base for most modern cancer drugs."},{"id":"medical-cyclotrons-synthesis-modules","kind":"technology","name":"Medical cyclotrons, hot cells, and synthesis modules","route":"/technologies/medical-cyclotrons-synthesis-modules/","status":"standard-of-care","tldr":"The particle accelerators and shielded robotic chemistry boxes that make PET tracers in hospital basements and commercial pharmacies."},{"id":"radionuclide-generators-kits","kind":"technology","name":"Radionuclide generators and cold kits","route":"/technologies/radionuclide-generators-kits/","status":"standard-of-care","tldr":"Bench-top devices that 'milk' a short-lived isotope from a long-lived parent, plus vials of ready-to-label ligand. How most hospitals make PSMA and somatostatin PET tracers without a cyclotron."},{"id":"ngs-bioinformatics-software","kind":"technology","name":"Clinical NGS bioinformatics and variant interpretation","route":"/technologies/ngs-bioinformatics-software/","status":"established","tldr":"Software that turns raw sequencer output into a report of which mutations matter and which drugs they point to."},{"id":"genomics-cloud-platforms","kind":"technology","name":"Genomics cloud and secure research environments","route":"/technologies/genomics-cloud-platforms/","status":"established","tldr":"Cloud systems where hospitals and researchers store and analyse genomic data securely at petabyte scale."},{"id":"variant-knowledgebases","kind":"technology","name":"Cancer variant knowledgebases and molecular tumour boards","route":"/technologies/variant-knowledgebases/","status":"established","tldr":"Curated databases that say what each mutation means for treatment, and the expert meetings that use them to decide on therapy."},{"id":"cancer-registries-surveillance","kind":"technology","name":"Cancer registries and population surveillance","route":"/technologies/cancer-registries-surveillance/","status":"standard-of-care","tldr":"The public systems that count every cancer diagnosis and death in a country, which tell us whether incidence and survival are improving."},{"id":"proteomics-platforms","kind":"technology","name":"Proteomics instruments and affinity platforms","route":"/technologies/proteomics-platforms/","status":"established","tldr":"Machines that measure thousands of proteins at once from tissue or blood, used to find drug targets and early-detection markers."},{"id":"structural-biology-infrastructure","kind":"technology","name":"Structural biology infrastructure (cryo-EM, synchrotrons, AlphaFold)","route":"/technologies/structural-biology-infrastructure/","status":"established","tldr":"Structural biology infrastructure is the microscopes, X-ray sources, and prediction models that show what a cancer protein looks like so chemists can design a drug to fit it."},{"id":"high-throughput-screening-libraries","kind":"technology","name":"High-throughput screening and DNA-encoded libraries","route":"/technologies/high-throughput-screening-libraries/","status":"established","tldr":"Testing millions or billions of chemical compounds against a cancer target automatically to find starting points for new drugs."},{"id":"preanalytics-sample-stabilisation","kind":"technology","name":"Pre-analytics: blood-collection tubes and tissue fixation","route":"/technologies/preanalytics-sample-stabilisation/","status":"standard-of-care","tldr":"The tubes and fixatives that keep a sample stable between the patient and the lab. Unglamorous, but they decide whether a liquid biopsy or PD-L1 stain is trustworthy."},{"id":"ihc-autostainers-histology-automation","kind":"technology","name":"Histology automation and IHC autostainers","route":"/technologies/ihc-autostainers-histology-automation/","status":"standard-of-care","tldr":"Histology automation is the robots that process tissue into slides and stain them for biomarkers such as HER2 and PD-L1, the same way every time."},{"id":"infusion-devices-vascular-access","kind":"technology","name":"Infusion pumps, ports, and ambulatory chemotherapy devices","route":"/technologies/infusion-devices-vascular-access/","status":"standard-of-care","tldr":"Infusion devices are the implanted ports, smart pumps, and take-home pumps that deliver chemotherapy safely, including 46-hour infusions patients carry home."},{"id":"federated-learning-medical-ai","kind":"technology","name":"Federated learning and privacy-preserving AI","route":"/technologies/federated-learning-medical-ai/","status":"emerging","tldr":"Federated learning trains one AI model across hospitals by exchanging model updates, not patient data, so a pathology or radiology model learns from every site while records stay behind each firewall. Owkin, NVIDIA FLARE and the MELLODDY pharma consortium use it; governance overhead and differing data across sites are the practical obstacles."},{"id":"telemedicine-teleoncology","kind":"technology","name":"Telemedicine, teleoncology, and telepathology","route":"/technologies/telemedicine-teleoncology/","status":"established","tldr":"Video visits, remote second opinions, and slides reviewed from afar, which let rural and low-resource patients reach specialists."},{"id":"miltenyi-biotec","kind":"company","name":"Miltenyi Biotec","route":"/companies/miltenyi-biotec/","tldr":"Miltenyi Biotec, a private German company, makes the CliniMACS Prodigy, a closed automated device that manufactures CAR-T cells at the point of care, plus the magnetic cell separation and lentiviral vectors behind it, and its own CD20/CD19 bispecific CAR-T is in late-stage lymphoma trials."},{"id":"lonza","kind":"company","name":"Lonza","route":"/companies/lonza/","tldr":"Lonza is the largest contract manufacturer for biologics, ADCs, and cell therapies, and owns the Synaffix ADC linker technology and the Cocoon cell-manufacturing platform."},{"id":"cellares","kind":"company","name":"Cellares","route":"/companies/cellares/","tldr":"Cellares builds the Cell Shuttle, a fully automated 'smart factory' for cell therapies, with BMS and Kite as partners."},{"id":"cytiva","kind":"company","name":"Cytiva (Danaher)","route":"/companies/cytiva/","tldr":"Danaher's bioprocessing arm (formerly GE Healthcare Life Sciences), supplying the Sefia cell-therapy platform, chromatography, and single-use systems."},{"id":"galapagos","kind":"company","name":"Galapagos","route":"/companies/galapagos/","tldr":"Galapagos is a biotech pursuing decentralised, seven-day vein-to-vein CAR-T manufacturing at hospital sites; it restructured its cell-therapy business in 2025."},{"id":"oxford-biomedica","kind":"company","name":"OXB (Oxford Biomedica)","route":"/companies/oxford-biomedica/","tldr":"Pure-play viral vector CDMO that made lentiviral vector for Kymriah and manufactured the AstraZeneca COVID vaccine."},{"id":"thermo-fisher","kind":"company","name":"Thermo Fisher Scientific","route":"/companies/thermo-fisher/","tldr":"Thermo Fisher is the largest life-science tools and services company, spanning Ion Torrent sequencing (Oncomine), viral vector and fill-finish manufacturing (Patheon), and the PPD clinical research organisation."},{"id":"charles-river","kind":"company","name":"Charles River Laboratories","route":"/companies/charles-river/","tldr":"Preclinical CRO for safety and discovery studies, with viral vector and cell-therapy manufacturing services."},{"id":"aldevron","kind":"company","name":"Aldevron (Danaher)","route":"/companies/aldevron/","tldr":"Leading GMP plasmid DNA and mRNA raw-material supplier, acquired by Danaher for $9.6B in 2021."},{"id":"touchlight","kind":"company","name":"Touchlight","route":"/companies/touchlight/","tldr":"Touchlight, of Hampton in the United Kingdom, makes doggybone dbDNA, synthetic DNA produced enzymatically without bacterial cells, as a replacement for plasmids in viral vector and mRNA manufacturing. Its business depends on regulators and developers accepting synthetic DNA in licensed products, not only in development."},{"id":"wuxi-xdc","kind":"company","name":"WuXi XDC","route":"/companies/wuxi-xdc/","tldr":"WuXi XDC is the largest dedicated ADC CDMO, spun out of WuXi Biologics and listed in Hong Kong in 2023; it is exposed to US BIOSECURE Act politics."},{"id":"samsung-biologics","kind":"company","name":"Samsung Biologics","route":"/companies/samsung-biologics/","tldr":"Samsung Biologics is the world's largest biologics CDMO by capacity, and opened a dedicated ADC conjugation facility in 2025."},{"id":"piramal-pharma-solutions","kind":"company","name":"Piramal Pharma Solutions","route":"/companies/piramal-pharma-solutions/","tldr":"Piramal Pharma Solutions, a Mumbai contract manufacturer, links cytotoxic payloads to antibodies at Grangemouth in Scotland, one of the few ADC conjugation sites in the West, and runs contained sites in the United States and India for drug substances too toxic to handle openly. Whether it can capture the ADC demand leaving China is its open question."},{"id":"abzena","kind":"company","name":"Abzena","route":"/companies/abzena/","tldr":"Abzena is a bioconjugation and biologics CDMO with the ThioBridge site-specific linker technology."},{"id":"catalent","kind":"company","name":"Catalent (Novo Holdings)","route":"/companies/catalent/","tldr":"Catalent, of Somerset, New Jersey, is a contract manufacturer that fills and finishes sterile injectables and makes biologics and cell and gene therapies; Novo Holdings bought it in 2024 and moved three sites to Novo Nordisk. The diversion of fill-finish capacity to obesity drugs may squeeze oncology products."},{"id":"petnet-solutions","kind":"company","name":"PETNET Solutions (Siemens Healthineers)","route":"/companies/petnet-solutions/","tldr":"PETNET Solutions is the largest network of PET radiopharmacies in the US, producing FDG and PSMA tracers daily."},{"id":"cardinal-health","kind":"company","name":"Cardinal Health Nuclear & Precision Health Solutions","route":"/companies/cardinal-health/","tldr":"Nuclear pharmacy network (>130 sites) that compounds and delivers SPECT and PET doses, and a distributor of oncology drugs to community practices."},{"id":"jubilant-radiopharma","kind":"company","name":"Jubilant Radiopharma","route":"/companies/jubilant-radiopharma/","tldr":"Jubilant Radiopharma is a radiopharmacy network and the manufacturer of I-131 MIBG (AdreView), Ruby-Fill, and PET tracers."},{"id":"northstar-medical-radioisotopes","kind":"company","name":"NorthStar Medical Radioisotopes","route":"/companies/northstar-medical-radioisotopes/","tldr":"NorthStar is a non-reactor producer of Mo-99 in the US and an emerging supplier of non-carrier-added Lu-177 and Ac-225 made with electron accelerators."},{"id":"shine-technologies","kind":"company","name":"SHINE Technologies","route":"/companies/shine-technologies/","tldr":"SHINE Technologies is a fusion-based isotope company that produces non-carrier-added Lu-177 (Ilumira) and is building the Chrysalis Mo-99 plant."},{"id":"eckert-ziegler","kind":"company","name":"Eckert & Ziegler","route":"/companies/eckert-ziegler/","tldr":"German isotope and radiopharmaceutical services company supplying Lu-177, Ga-68 generators, Ac-225 development, and contract manufacturing."},{"id":"pacbio","kind":"company","name":"PacBio","route":"/companies/pacbio/","tldr":"Long-read HiFi sequencing (Revio, Vega) for structural variants, phasing, and methylation."},{"id":"oxford-nanopore","kind":"company","name":"Oxford Nanopore Technologies","route":"/companies/oxford-nanopore/","tldr":"Portable and high-throughput nanopore sequencing, used for rapid intraoperative brain-tumour classification and structural variant detection."},{"id":"ultima-genomics","kind":"company","name":"Ultima Genomics","route":"/companies/ultima-genomics/","tldr":"Open-wafer sequencing (UG 100) claiming a $100 genome, aimed at population-scale and deep ctDNA sequencing."},{"id":"element-biosciences","kind":"company","name":"Element Biosciences","route":"/companies/element-biosciences/","tldr":"AVITI benchtop sequencer with avidity chemistry, competing on accuracy and cost with mid-throughput Illumina systems."},{"id":"mgi-tech","kind":"company","name":"MGI Tech","route":"/companies/mgi-tech/","tldr":"Chinese sequencing-instrument maker (DNBSEQ), Illumina's main rival by volume, restricted in the US by the BIOSECURE Act."},{"id":"bruker","kind":"company","name":"Bruker (Bruker Spatial Biology)","route":"/companies/bruker/","tldr":"Scientific-instrument group that acquired NanoString (GeoMx, CosMx) out of bankruptcy in 2024 to form Bruker Spatial Biology."},{"id":"vizgen","kind":"company","name":"Vizgen","route":"/companies/vizgen/","tldr":"Vizgen sells the MERSCOPE spatial transcriptomics platform, based on MERFISH from Xiaowei Zhuang's lab."},{"id":"akoya-biosciences","kind":"company","name":"Akoya Biosciences","route":"/companies/akoya-biosciences/","tldr":"Spatial proteomics (PhenoCycler, PhenoImager) used to map immune cells in tumours; agreed to be acquired by Quanterix (2025)."},{"id":"leica-biosystems","kind":"company","name":"Leica Biosystems (Danaher)","route":"/companies/leica-biosystems/","tldr":"Leica Biosystems, part of Danaher and based in Nussloch, Germany, makes the Aperio slide scanners (the GT 450 DX is FDA-cleared), the BOND immunohistochemistry stainers and companion diagnostic assays that pathology laboratories use to stain and digitise tissue. Whether routine pathology fully leaves the glass slide depends on suppliers like it."},{"id":"hamamatsu","kind":"company","name":"Hamamatsu Photonics","route":"/companies/hamamatsu/","tldr":"Hamamatsu is the photonics company behind the NanoZoomer slide scanners and the photodetectors inside most PET scanners."},{"id":"3dhistech","kind":"company","name":"3DHISTECH","route":"/companies/3dhistech/","tldr":"3DHISTECH, of Budapest, makes the Pannoramic slide scanners, including the high-throughput Pannoramic 1000, and the SlideViewer software used in research and European clinical laboratories, distributed by Epredia and Thermo Fisher in some markets. As digital pathology consolidates around a few large vendors, holding its position is the open question."},{"id":"philips","kind":"company","name":"Philips","route":"/companies/philips/","tldr":"Imaging and health-informatics company: MRI, CT, and the IntelliSite digital pathology system that won the first FDA clearance for primary diagnosis."},{"id":"sectra","kind":"company","name":"Sectra","route":"/companies/sectra/","tldr":"Sectra, of Linköping, Sweden, makes enterprise imaging and digital pathology software whose PACS and Digital Pathology module run national-scale fully digital pathology in the Netherlands, the United Kingdom and Sweden. Whether that delivers faster diagnoses and better use of scarce pathologists is still being tested."},{"id":"proscia","kind":"company","name":"Proscia","route":"/companies/proscia/","tldr":"Proscia makes the Concentriq digital pathology platform for labs and pharma, with an AI marketplace."},{"id":"indica-labs","kind":"company","name":"Indica Labs","route":"/companies/indica-labs/","tldr":"Indica Labs, of Albuquerque, New Mexico, makes HALO, image analysis software that quantifies stained tissue on digital slides, and HALO Link for enterprise viewing, sold to pharmaceutical and academic pathology laboratories; HALO AP Dx is cleared for clinical use in several regions. Crossing from research tool to regulated diagnosis is its test."},{"id":"raysearch","kind":"company","name":"RaySearch Laboratories","route":"/companies/raysearch/","tldr":"RaySearch makes the vendor-neutral RayStation treatment planning system, strong in proton and adaptive planning, with machine-learning planning tools."},{"id":"sun-nuclear","kind":"company","name":"Sun Nuclear (Mirion)","route":"/companies/sun-nuclear/","tldr":"Radiotherapy quality-assurance instruments and software (SunCHECK, ArcCHECK) that verify machines deliver the planned dose."},{"id":"brainlab","kind":"company","name":"Brainlab","route":"/companies/brainlab/","tldr":"Surgical navigation and radiosurgery planning software (Elements), used in neurosurgery and stereotactic radiotherapy."},{"id":"limbus-ai","kind":"company","name":"Limbus AI","route":"/companies/limbus-ai/","tldr":"Limbus AI provides AI auto-contouring for radiotherapy, FDA-cleared and used across hundreds of centres."},{"id":"mim-software","kind":"company","name":"MIM Software (GE HealthCare)","route":"/companies/mim-software/","tldr":"Contouring, image fusion, and dosimetry software (MIM Maestro, SurePlan) for radiotherapy and radioligand therapy, acquired by GE HealthCare in 2024."},{"id":"therapanacea","kind":"company","name":"TheraPanacea","route":"/companies/therapanacea/","tldr":"TheraPanacea is a Paris AI company whose ART-Plan does auto-contouring and synthetic CT in radiotherapy."},{"id":"mvision-ai","kind":"company","name":"MVision AI","route":"/companies/mvision-ai/","tldr":"MVision AI is a Finnish auto-contouring company with guideline-based organ and target segmentation."},{"id":"flatiron-health","kind":"company","name":"Flatiron Health (Roche)","route":"/companies/flatiron-health/","tldr":"Oncology EHR (OncoEMR) and the largest curated real-world oncology database, acquired by Roche for $1.9B in 2018."},{"id":"concertai","kind":"company","name":"ConcertAI","route":"/companies/concertai/","tldr":"Oncology real-world data and AI company (ex-CancerLinQ data partner), supplying pharma and FDA-facing studies."},{"id":"cota-healthcare","kind":"company","name":"COTA","route":"/companies/cota-healthcare/","tldr":"Curated oncology real-world data with clinically abstracted endpoints, used in FDA-recognised RWE studies."},{"id":"trinetx","kind":"company","name":"TriNetX","route":"/companies/trinetx/","tldr":"Federated real-world data network across health systems, used for trial feasibility and observational studies."},{"id":"komodo-health","kind":"company","name":"Komodo Health","route":"/companies/komodo-health/","tldr":"Claims-based 'Healthcare Map' of 330 million US patients used for market and outcomes analytics in oncology."},{"id":"datavant","kind":"company","name":"Datavant","route":"/companies/datavant/","tldr":"Privacy-preserving record linkage (tokenisation) that lets real-world datasets be joined without exposing identities."},{"id":"medidata","kind":"company","name":"Medidata (Dassault Systèmes)","route":"/companies/medidata/","tldr":"Medidata, owned by Dassault Systèmes, makes Rave, the most used electronic data capture system in clinical trials, plus randomisation and outcome-assessment tools and synthetic control arms built from past trial data. Whether regulators accept synthetic controls for oncology approvals is the open question."},{"id":"veeva-systems","kind":"company","name":"Veeva Systems","route":"/companies/veeva-systems/","tldr":"Veeva Systems, of Pleasanton, California, sells cloud software for life sciences: its Vault Clinical suite, including Vault CDMS, captures and manages trial data, and separate Vault systems cover regulatory, quality and commercial work. One vendor spanning trials, regulation and marketing raises the question of whether trial data become more shareable or more locked in."},{"id":"oracle-health-sciences","kind":"company","name":"Oracle Health (Cerner) & Oracle Life Sciences","route":"/companies/oracle-health-sciences/","tldr":"Oracle owns the Cerner EHR (PowerChart Oncology) and the Oracle Clinical One trial platform."},{"id":"epic-systems","kind":"company","name":"Epic Systems","route":"/companies/epic-systems/","tldr":"Epic Systems is the dominant US hospital EHR; its Beacon oncology module handles chemotherapy ordering and Cosmos aggregates de-identified records for research."},{"id":"medable","kind":"company","name":"Medable","route":"/companies/medable/","tldr":"Medable is a decentralised clinical trial platform (eConsent, eCOA, telehealth)."},{"id":"science-37","kind":"company","name":"Science 37 (eMed)","route":"/companies/science-37/","tldr":"Pioneer of the 'metasite' decentralised trial model, acquired by eMed in 2024."},{"id":"mckesson-us-oncology","kind":"company","name":"McKesson / The US Oncology Network","route":"/companies/mckesson-us-oncology/","tldr":"McKesson runs the largest US community oncology network (about 3,000 providers) and distributes drugs, and co-owns the Sarah Cannon Research Institute."},{"id":"oneoncology","kind":"company","name":"OneOncology","route":"/companies/oneoncology/","tldr":"Physician-led community oncology network backed by TPG and Cencora (AmerisourceBergen), competing with US Oncology."},{"id":"florida-cancer-specialists","kind":"company","name":"Florida Cancer Specialists & Research Institute","route":"/companies/florida-cancer-specialists/","tldr":"Florida Cancer Specialists is one of the largest independent oncology practices in the US and a leading phase 1 enroller through its Drug Development Unit."},{"id":"sarah-cannon-research-institute","kind":"company","name":"Sarah Cannon Research Institute","route":"/companies/sarah-cannon-research-institute/","tldr":"Sarah Cannon Research Institute, of Nashville, is a community-based research network owned jointly by HCA Healthcare and McKesson whose drug development units across the United States and United Kingdom frequently host first-in-human oncology trials. Whether its community sites reach patients who would never travel to an academic centre, and how their outcomes compare, is untested."},{"id":"iqvia","kind":"company","name":"IQVIA","route":"/companies/iqvia/","tldr":"IQVIA is the largest CRO and health-data company, running a large share of global oncology trials and selling prescription and claims data."},{"id":"icon-plc","kind":"company","name":"ICON plc","route":"/companies/icon-plc/","tldr":"ICON is an Irish CRO (including PRA Health Sciences) with a large oncology franchise and an imaging core lab."},{"id":"parexel","kind":"company","name":"Parexel","route":"/companies/parexel/","tldr":"Parexel, of Durham, North Carolina, is a global contract research organisation owned by EQT and Goldman Sachs that runs early and late-phase oncology trials and sells regulatory consulting staffed by former FDA officials. Whether regulators moving into consulting sharpens trial design or blurs the line between regulator and industry is the question its model raises."},{"id":"fortrea","kind":"company","name":"Fortrea","route":"/companies/fortrea/","tldr":"Fortrea, of Durham, North Carolina, is the contract research organisation spun out of Labcorp in 2023 that runs clinical trials for sponsors and keeps ties to Labcorp's central laboratory, which handles trial samples. Competing for oncology programmes against much larger rivals without its parent's balance sheet is its open question."},{"id":"medpace","kind":"company","name":"Medpace","route":"/companies/medpace/","tldr":"Medpace, of Cincinnati, is a mid-sized full-service contract research organisation whose physician-led model keeps medical oversight, the imaging core laboratory and central laboratories in-house, a package that biotechnology companies buy for oncology programmes. Whether in-house imaging and laboratories give cleaner oncology endpoints than outsourcing is unproven."},{"id":"calyx","kind":"company","name":"Calyx","route":"/companies/calyx/","tldr":"Imaging core lab and RTSM provider (formerly Parexel Informatics), a leading vendor of blinded central review in oncology trials."},{"id":"clario","kind":"company","name":"Clario","route":"/companies/clario/","tldr":"Clario is the endpoint technology company (Bioclinica and ERT merger) for imaging, eCOA, and cardiac data in trials."},{"id":"discovery-life-sciences","kind":"company","name":"Discovery Life Sciences","route":"/companies/discovery-life-sciences/","tldr":"Discovery Life Sciences is a large commercial biospecimen and biomarker services provider (tissue, blood, cells) for pharma and diagnostics."},{"id":"indivumed","kind":"company","name":"Indivumed","route":"/companies/indivumed/","tldr":"Indivumed is a German biobank with standardised, rapidly processed tumour samples and a multi-omics database (IndivuType)."},{"id":"hub-organoids","kind":"company","name":"HUB Organoids","route":"/companies/hub-organoids/","tldr":"The Clevers-lab spin-out that licenses patient-derived organoid technology and maintains a living biobank."},{"id":"labcorp","kind":"company","name":"Labcorp","route":"/companies/labcorp/","tldr":"Labcorp is one of the two US national reference labs, running oncology IHC, FISH, and NGS at scale and central labs for trials."},{"id":"quest-diagnostics","kind":"company","name":"Quest Diagnostics","route":"/companies/quest-diagnostics/","tldr":"Quest Diagnostics is a national reference laboratory with oncology pathology and molecular testing, including Haystack Oncology MRD (acquired 2023)."},{"id":"neogenomics","kind":"company","name":"NeoGenomics","route":"/companies/neogenomics/","tldr":"Cancer-focused reference lab for IHC, FISH, flow cytometry, and NGS, serving community oncology and pharma."},{"id":"agilent","kind":"company","name":"Agilent Technologies (Dako)","route":"/companies/agilent/","tldr":"Agilent makes the Dako PD-L1 IHC 22C3 and 28-8 companion diagnostics and the Omnis staining platform."},{"id":"canon-medical","kind":"company","name":"Canon Medical Systems","route":"/companies/canon-medical/","tldr":"Canon Medical is the Japanese imaging vendor (formerly Toshiba Medical) with CT, MRI, ultrasound, and the Cartesion Prime PET/CT."},{"id":"kaiku-health","kind":"company","name":"Kaiku Health (Elekta)","route":"/companies/kaiku-health/","tldr":"Digital patient-monitoring platform for cancer care, acquired by Elekta in 2020."},{"id":"omnicell","kind":"company","name":"Omnicell","route":"/companies/omnicell/","tldr":"Omnicell is a pharmacy automation company whose IV compounding systems prepare chemotherapy safely."},{"id":"becton-dickinson","kind":"company","name":"BD (Becton, Dickinson and Company)","route":"/companies/becton-dickinson/","tldr":"Medical technology company supplying closed-system transfer devices (PhaSeal), infusion systems, flow cytometers, and single-cell tools."},{"id":"microsoft","kind":"company","name":"Microsoft (Health & Life Sciences)","route":"/companies/microsoft/","tldr":"Cloud and AI provider behind pathology foundation models (Prov-GigaPath with Providence, Virchow hosting with Paige) and Nuance clinical AI."},{"id":"google-health","kind":"company","name":"Google (Health, DeepMind, Verily)","route":"/companies/google-health/","tldr":"Alphabet's health efforts: mammography and pathology AI research, Med-PaLM/MedGemma medical models, DeepMind's AlphaFold, and Isomorphic Labs drug design."},{"id":"civica-rx","kind":"company","name":"Civica Rx","route":"/companies/civica-rx/","tldr":"Non-profit generic drug maker formed by hospital systems to secure supply of essential injectables, including oncology drugs."},{"id":"terumo-bct","kind":"company","name":"Terumo Blood and Cell Technologies","route":"/companies/terumo-bct/","tldr":"Maker of the Spectra Optia apheresis system used to collect cells for most CAR-T products, and of the Quantum cell-expansion system."},{"id":"fresenius-kabi","kind":"company","name":"Fresenius Kabi","route":"/companies/fresenius-kabi/","tldr":"Fresenius Kabi, of Bad Homburg, Germany, supplies the Amicus and LOVO apheresis devices that collect and process cells for cell therapy, a large portfolio of generic chemotherapy injectables, biosimilars and infusion products. Its generics have filled gaps during injectable shortages, which keep recurring because the economics of generic injectables remain unfixed."},{"id":"cryoport","kind":"company","name":"Cryoport","route":"/companies/cryoport/","tldr":"Cryoport is a specialist cryogenic logistics provider supporting most commercial CAR-T products and hundreds of cell-therapy trials."},{"id":"biolife-solutions","kind":"company","name":"BioLife Solutions","route":"/companies/biolife-solutions/","tldr":"Maker of CryoStor freeze media used in most approved cell therapies, plus evo cold-chain shippers."},{"id":"fujifilm-diosynth","kind":"company","name":"FUJIFILM Diosynth Biotechnologies","route":"/companies/fujifilm-diosynth/","tldr":"FUJIFILM Diosynth Biotechnologies, headquartered in Tokyo, is a biologics contract manufacturer offering mammalian and microbial production and cell and gene therapy services, and is adding antibody capacity in Denmark and North Carolina, where its Holly Springs site is among the world's largest. Whether new capacity outruns demand once the biggest antibody patents expire is the sector's question."},{"id":"boehringer-ingelheim-biox","kind":"company","name":"Boehringer Ingelheim BioXcellence","route":"/companies/boehringer-ingelheim-biox/","tldr":"Boehringer Ingelheim BioXcellence is the contract-manufacturing arm of Boehringer Ingelheim, one of the largest antibody producers by volume."},{"id":"trasis","kind":"company","name":"Trasis","route":"/companies/trasis/","tldr":"Belgian maker of radiopharmaceutical synthesis modules (AllinOne, miniAiO) and dose dispensers used in PET and therapy radiopharmacies."},{"id":"comecer","kind":"company","name":"Comecer (ATS)","route":"/companies/comecer/","tldr":"Comecer, of Castel Bolognese, Italy, and part of ATS Corporation, makes hot cells, isolators and dose calibrators, the shielded enclosures and automation that radiopharmacies need to handle radioactive drugs aseptically. Therapeutic radioligands need more shielding than diagnostic tracers, and whether hospitals build enough of it is the open question."},{"id":"sophia-genetics","kind":"company","name":"SOPHiA GENETICS","route":"/companies/sophia-genetics/","tldr":"Cloud platform (SOPHiA DDM) that hospitals use to analyse and interpret NGS oncology panels."},{"id":"qiagen","kind":"company","name":"QIAGEN","route":"/companies/qiagen/","tldr":"QIAGEN is a sample-preparation and molecular-diagnostics company selling nucleic-acid extraction kits, therascreen companion diagnostics, and QCI Interpret software."},{"id":"velsera","kind":"company","name":"Velsera (Seven Bridges and Pierian)","route":"/companies/velsera/","tldr":"Genomics cloud and clinical interpretation company formed from Seven Bridges, Pierian, and UgenTec in 2023; operates the NCI Cancer Genomics Cloud."},{"id":"dnanexus","kind":"company","name":"DNAnexus","route":"/companies/dnanexus/","tldr":"DNAnexus, of Mountain View, California, runs the secure genomics cloud platform behind the UK Biobank Research Analysis Platform and Genomics England, giving biobanks, drug companies and clinical laboratories a compliant place to store and analyse sequencing data. Whether such trusted environments open data to more researchers without weakening privacy is what those deployments test."},{"id":"standard-biotools","kind":"company","name":"Standard BioTools (SomaLogic)","route":"/companies/standard-biotools/","tldr":"Proteomics and mass-cytometry company that merged with SomaLogic (SomaScan aptamer proteomics) in 2024."},{"id":"streck","kind":"company","name":"Streck","route":"/companies/streck/","tldr":"Streck makes the Cell-Free DNA BCT blood tube that made shippable liquid biopsy practical."},{"id":"sakura-finetek","kind":"company","name":"Sakura Finetek","route":"/companies/sakura-finetek/","tldr":"Sakura Finetek is a histology automation leader (Tissue-Tek processors, embedders, stainers, and the Genie IHC platform)."},{"id":"baxter","kind":"company","name":"Baxter International","route":"/companies/baxter/","tldr":"Infusion pumps (Spectrum, Novum), elastomeric ambulatory pumps (Infusor), IV fluids and generic injectables."},{"id":"b-braun","kind":"company","name":"B. Braun","route":"/companies/b-braun/","tldr":"German medical-device company supplying Celsite ports, Easypump elastomeric pumps, infusion systems, and cytotoxic-safe consumables."}]}