{"slug":"synthetic-lethality","tag":"synthetic-lethality","variants":["synthetic-lethality"],"description":"No description yet","count":2,"kinds":{"target":1,"person":1},"related":[{"slug":"discovery","tag":"discovery","shared":1},{"slug":"parp","tag":"parp","shared":1}],"records":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/","tldr":"PARP is a DNA repair enzyme. Cancers that have already lost one repair system (BRCA) die when this second one is blocked; healthy cells survive."},{"id":"thomas-helleday","kind":"person","name":"Thomas Helleday","route":"/people/thomas-helleday/","tldr":"Co-discovered that PARP inhibitors kill BRCA-deficient cells, the synthetic lethality behind olaparib and its successors."}]}