{"slug":"tcr-target","tag":"tcr-target","variants":["tcr-target"],"description":"No description yet","count":3,"kinds":{"target":3},"related":[],"records":[{"id":"prame","kind":"target","name":"PRAME","route":"/targets/prame/","tldr":"PRAME is a cancer-testis antigen: a protein normally confined to the testis that about 90% of cutaneous melanomas and substantial fractions of ovarian, lung, endometrial and uveal cancers switch on. Because it sits inside the cell, drugs reach it only as peptide fragments displayed on HLA, through T-cell receptor bispecifics such as brenetafusp and TCR-T cells such as IMA203."},{"id":"mage-a4","kind":"target","name":"MAGE-A4","route":"/targets/mage-a4/","tldr":"A protein normally only in testis that some sarcomas and other tumours switch on; T cells can be engineered to recognise fragments of it."},{"id":"gp100","kind":"target","name":"gp100 (PMEL)","route":"/targets/gp100/","tldr":"gp100 is a pigment-cell protein, and the target of the first bispecific drug to improve survival in a solid tumour, uveal melanoma."}]}