{"slug":"tp53","tag":"tp53","variants":["tp53"],"description":"No description yet","count":1,"kinds":{"biomarker":1},"related":[{"slug":"biomarker","tag":"biomarker","shared":1}],"records":[{"id":"tp53-del17p","kind":"biomarker","name":"TP53 mutation and del(17p)","route":"/biomarkers/tp53-del17p/","tldr":"TP53 mutation, or deletion of the 17p arm that carries the gene, is the single most common change in cancer and carries a worse outlook almost everywhere. In chronic lymphocytic leukaemia it decides treatment: chemotherapy is avoided and venetoclax's first approval was for del(17p) disease."}]}