[{"id":"epigenetic-editing","kind":"technology","name":"Epigenetic editing (durable gene silencing)","route":"/technologies/epigenetic-editing/","commit":"0bdbdae6c6","date":"2026-09-09","author":"Jude Gomila","message":"Editing pass: every TL;DR and summary stands alone","file":"src/data/frontier.ts","type":"changed","fields":[{"field":"summary","before":"\"CRISPRoff-style effectors fuse a dead Cas protein to DNA methyltransferase and repressor domains, imposing heritable silencing that survives cell division. Tune Therapeutics and Chroma Medicine took the approach into...","after":"\"CRISPRoff-style effectors fuse a dead Cas protein to DNA methyltransferase and repressor domains, imposing heritable silencing that survives cell division. Tune Therapeutics and Chroma Medicine took the approach into..."},{"field":"limitations","before":"[\"No oncology trial as of 2026\", \"Delivery to solid tumours unsolved\", \"Escape by cells that lose the mark or the dependency\"]","after":"[\"No oncology trial yet (2026)\", \"Delivery to solid tumours unsolved\", \"Escape by cells that lose the mark or the dependency\"]"}]},{"id":"epigenetic-editing","kind":"technology","name":"Epigenetic editing (durable gene silencing)","route":"/technologies/epigenetic-editing/","commit":"5c85c736e1","date":"2026-09-08","author":"Jude Gomila","message":"data(frontier): 45 radical frontier technologies and two horizon roadmaps","file":"src/data/frontier.ts","type":"added","fields":[{"field":"id"},{"field":"kind"},{"field":"name"},{"field":"sections"},{"field":"status"},{"field":"asOf"},{"field":"tldr"},{"field":"summary"},{"field":"principle"},{"field":"strengths"},{"field":"limitations"},{"field":"technologies"},{"field":"tags"},{"field":"links"}]}]