[{"id":"in-vivo-gene-editing-cancer","kind":"technology","name":"In vivo base and prime editing for cancer","route":"/technologies/in-vivo-gene-editing-cancer/","commit":"0bdbdae6c6","date":"2026-09-09","author":"Jude Gomila","message":"Editing pass: every TL;DR and summary stands alone","file":"src/data/frontier.ts","type":"changed","fields":[{"field":"tldr","before":"\"Rewriting a cancer's DNA letter by letter inside the body. It works in the liver for inherited disease; nobody has yet corrected a cancer this way in a person.\"","after":"\"In vivo base and prime editing would rewrite a cancer's DNA letter by letter inside the body. It works in the liver for inherited disease; nobody has yet corrected a cancer this way in a person.\""},{"field":"summary","before":"\"Base editors change a single DNA letter without cutting; prime editors write short new sequences. Both are in the clinic for inherited liver and blood disease, and base editing is used ex vivo to build allogeneic CAR...","after":"\"Base editors change a single DNA letter without cutting; prime editors write short new sequences. Both are in the clinic for inherited liver and blood disease, and base editing is used ex vivo to build allogeneic CAR..."},{"field":"limitations","before":"[\"No in vivo oncology trial as of 2026\", \"Delivery reaches liver far better than solid tumours\", \"Editing a fraction of cells may not change tumour behaviour\", \"Off-target edits are permanent\"]","after":"[\"No in vivo oncology trial yet (2026)\", \"Delivery reaches liver far better than solid tumours\", \"Editing a fraction of cells may not change tumour behaviour\", \"Off-target edits are permanent\"]"}]},{"id":"in-vivo-gene-editing-cancer","kind":"technology","name":"In vivo base and prime editing for cancer","route":"/technologies/in-vivo-gene-editing-cancer/","commit":"5c85c736e1","date":"2026-09-08","author":"Jude Gomila","message":"data(frontier): 45 radical frontier technologies and two horizon roadmaps","file":"src/data/frontier.ts","type":"added","fields":[{"field":"id"},{"field":"kind"},{"field":"name"},{"field":"sections"},{"field":"status"},{"field":"asOf"},{"field":"tldr"},{"field":"summary"},{"field":"principle"},{"field":"strengths"},{"field":"limitations"},{"field":"technologies"},{"field":"targets"},{"field":"tags"},{"field":"links"}]}]