A public registry of cancer treatments that were later shown not to work
Keep a running, well-documented list of cancer practices and approvals that were reversed by later evidence, so the pattern of mistakes is visible and teachable.
Medical reversals (for example high-dose chemotherapy with stem-cell rescue in breast cancer, several accelerated approvals later withdrawn, bevacizumab in breast cancer) are scattered across the literature. A curated registry with, for each reversal, the original evidence, the reversing trial, the time to reversal, the patients exposed, and the design features that allowed the error would inform regulators and teach trainees.
- Failures are hidden · Negative trials, failed drugs and abandoned programmes are rarely published, so the same mistakes are repeated.
- Knowledge reaches practice too slowly · Knowledge diffusion is slow: it takes years for a proven result to change what most patients receive, and no one can keep up with the literature.
Pages like this
not linked directly; found by shared links- IdeaPublish every complete response letter and negative opinion across all regulators
Shares FDA Oncology Approvals (OCE) & Novel Drug Approvals, Failures are hidden.
- IdeaA public index of how the same cancer drug's label differs between countries
Shares FDA Oncology Approvals (OCE) & Novel Drug Approvals, Knowledge reaches practice too slowly.
- IdeaA 'dose evidence' panel in every label: how many doses were tested, and how
Shares FDA Oncology Approvals (OCE) & Novel Drug Approvals, Knowledge reaches practice too slowly.
- IdeaPrint the participation-to-prevalence ratio in every drug label and assessment report
Shares FDA Oncology Approvals (OCE) & Novel Drug Approvals, Knowledge reaches practice too slowly.
- IdeaConditional approvals that lapse automatically if the confirmatory trial is late
Shares FDA Oncology Approvals (OCE) & Novel Drug Approvals, Accelerated approval.
- IdeaA target de-risking index that counts failures as well as successes
Shares A machine-readable taxonomy of why cancer drugs fail, Failures are hidden.
- IdeaRequire every oncology candidate to publish how much reaches the brain
Shares FDA Oncology Approvals (OCE) & Novel Drug Approvals, Failures are hidden, Knowledge reaches practice too slowly.
- IdeaPublic post-mortem reports when a cancer drug programme is stopped
Shares A machine-readable taxonomy of why cancer drugs fail, Failures are hidden, Knowledge reaches practice too slowly.