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Diet, Exercise & Lifestyle

What people eat, drink, weigh and do affects who gets cancer, how treatment goes, and who relapses. This front studies that with the rigour of a drug trial.

Obesity, alcohol and inactivity are established causes; diet quality, fibre and the gut microbiome shape immunotherapy response; structured exercise improved survival in a randomised colon cancer trial (CHALLENGE, 2025); fasting-mimicking and ketogenic diets, GLP-1 agonists, vitamin D and aspirin are under test. Cachexia and malnutrition during treatment are treatable and under-treated. The evidence ranges from strong to hype, and this front keeps the two apart.

Diet, Exercise & Lifestyle: how this front works · animated schematic, not to scale

Technologies

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Established
Alcohol reduction, pricing and cancer warning labels

Alcohol causes at least seven cancers and there is no safe threshold. Price, availability and cancer warning labels are the tools that work; most people still do not know alcohol causes cancer.

Phase 3
Aspirin for cancer prevention and adjuvant therapy

Daily low-dose aspirin lowers bowel cancer risk in people with Lynch syndrome and appears to cut recurrence in bowel cancers with a particular mutation. In healthy older people it caused more harm than good.

Established
Bariatric surgery and cancer incidence

People with severe obesity who have weight-loss surgery develop about a third fewer cancers over the following decade, especially womb and other hormone-related cancers, than similar people who do not.

Phase 3
Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine

Cachexia pharmacotherapy covers three drug approaches to cancer wasting: a new antibody that blocks the hormone suppressing appetite, an appetite hormone mimic approved only in Japan, and a very cheap old tablet. None is yet standard everywhere; all beat what came before.

Phase 3
Cachexia-directed therapy (GDF-15 blockade)

Treating the wasting that kills many cancer patients, by blocking the hormone that suppresses appetite.

Phase 2
Chronotherapy: timing treatment to the body clock

Giving the same drug at a different time of day, because the body clock changes how much damage it does and how well the immune system responds.

Established
Coffee and tea intake

Coffee does not cause cancer and is probably protective against liver and womb cancer. Very hot drinks of any kind may raise oesophageal cancer risk.

Emerging
Dietary fibre and the gut microbiome for immunotherapy response

Patients who eat plenty of fibre and avoid probiotic pills seem to respond better to immunotherapy for melanoma, probably because fibre feeds the right gut bacteria. A proper trial is under way.

Established
Dietary supplements during cancer treatment: interactions and harms

Most people on cancer treatment take supplements, often without telling their team. Antioxidants, St John's wort, high-dose vitamins and some herbs can blunt chemotherapy or radiotherapy or interact with targeted drugs.

Phase 3
Dietitian-led weight-loss programmes in HR-positive breast cancer

Being overweight after breast cancer is linked with more recurrence, so a 3,000-woman trial tested a two-year telephone weight-loss programme. Women lost weight, but the trial did not clearly show fewer recurrences.

Standard of care
Enhanced recovery (ERAS) and perioperative nutrition

Instead of starving patients before and after an operation, modern surgical pathways feed them early, give carbohydrate drinks the night before, and get them walking the next day. Complications and hospital stays fall.

Established
Enteral and parenteral nutrition support

Nutrition support means tube feeding into the gut, or nutrition into a vein when the gut cannot be used. It is life-saving in the right patient, harmful or futile in the wrong one.

Established
Exercise & lifestyle oncology

Structured exercise during and after treatment, which the CHALLENGE trial showed improves survival in colon cancer.

Established
Exercise during chemotherapy and radiotherapy

Moderate exercise while on chemotherapy is safe and reduces fatigue, helps people finish their planned doses, and may protect the heart and nerves.

Phase 2
Faecal microbiota transplantation for PD-1 non-responders

Transplanting gut bacteria from patients who responded to immunotherapy into those who did not. In small studies a minority of resistant melanomas started responding. Randomised trials are running.

Phase 2
Fasting and fasting-mimicking diets around chemotherapy

Eating very little for a few days around each chemotherapy dose might protect normal cells and sensitise the tumour. Early trials are intriguing but small, and it is not something to try without a dietitian.

Emerging
GLP-1 receptor agonists and obesity-related cancer risk

GLP-1 agonists, the new weight-loss injections, lower weight by 15-20%. Early observational data suggest fewer obesity-related cancers in people who take them, but no trial has yet tested cancer as an outcome.

Emerging
Immunonutrition before cancer surgery

Drinks enriched with arginine, omega-3 fats and nucleotides for a week before a big operation seem to reduce infections afterwards, though the trials are old and mostly industry-funded.

Phase 2
Ketogenic diets in glioblastoma

A ketogenic diet is a very-low-carbohydrate, high-fat diet that makes the body run on ketones. The idea is to starve brain tumours of glucose. It is safe and feasible for a few months, but no trial has shown it makes people live longer.

Established
Mediterranean and plant-forward dietary patterns

Diets built around vegetables, wholegrains, legumes, nuts, fish and olive oil, with little red or processed meat, are linked with lower cancer risk and better survival after diagnosis. The evidence is strong for the pattern, weak for any single food.

Phase 2
Metabolic therapy: starving the tumour of a nutrient

Removing an amino acid or nutrient that certain tumours cannot make for themselves, while normal cells can.

Phase 2
Microbiome modulation to unlock immunotherapy

Changing the gut bacteria of a patient whose immunotherapy stopped working, in the hope of restarting the response.

Established
Nutrition support and cachexia management

Screening for malnutrition, dietitian-led counselling, supplements and tube or intravenous feeding where indicated, plus treatment of cancer cachexia, the muscle-wasting syndrome that affects up to 80% of advanced patients.

Established
Oncology nutrition assessment and medical nutrition therapy

Nutrition screening means weighing every patient, asking a few screening questions, and referring those at risk to a dietitian. It is simple, guideline-endorsed, and still not done routinely.

Emerging
Prehabilitation before cancer surgery

Prehabilitation is a few weeks of structured exercise, nutrition and psychological preparation between diagnosis and surgery to make patients fitter for the operation and speed recovery.

Emerging
Probiotics, antibiotics and stewardship around immunotherapy

Antibiotics in the weeks before immunotherapy are linked with worse outcomes, and shop-bought probiotics may not help and might hurt. Avoiding both where possible is a low-cost precaution.

Established
Red and processed meat reduction

Processed meat (bacon, ham, sausages) definitely causes bowel cancer; red meat probably does. The risk per person is modest, but because so many people eat it, the population impact is large.

Emerging
Resistance training and protein for cachexia and sarcopenia

Lifting weights and eating enough protein is the only treatment shown to build muscle in people with cancer wasting, but most are too unwell to do it alone and the trials are small.

Emerging
Sleep and circadian interventions in cancer

Half of people with cancer sleep badly, so sleep and body-clock interventions matter. Talking therapy for insomnia works well and is under-used; whether fixing sleep or body-clock disruption changes the cancer itself is unproven.

Established
Smoking cessation in cancer patients

Stopping smoking after a cancer diagnosis improves survival, reduces treatment complications and second cancers, and is the single most effective supportive intervention that oncology services still routinely fail to deliver.

Established
Soy foods and breast cancer

For years women with breast cancer were told to avoid soy because it contains plant oestrogens. Large studies show moderate soy food intake is safe and may slightly reduce recurrence, including on tamoxifen.

Established
Structured exercise programmes after curative treatment

A supervised, coached exercise programme for three years after bowel cancer treatment cut recurrence and death in a large randomised trial. It is the first lifestyle intervention proven to work like an adjuvant drug.

Phase 2
Time-restricted eating in cancer prevention and survivorship

Time-restricted eating means eating within a window of 8-12 hours a day and fasting overnight. It improves blood sugar and weight a little; whether it changes cancer risk or recurrence is unknown.

Emerging
Ultra-processed food and sugar-sweetened drinks

Diets high in industrially processed foods and sugary drinks are linked with more cancer, mainly through obesity but perhaps also through additives and packaging chemicals. Sugar itself does not 'feed' a tumour in the way social media claims.

Phase 3
Vitamin D and omega-3 supplementation

The largest trial of vitamin D and fish-oil pills found they did not prevent cancer. A possible reduction in cancer deaths, and hints of benefit after a digestive cancer diagnosis, keep the question alive.

Key papers

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Connected

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technologies

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Alcohol reduction, pricing and cancer warning labelsAspirin for cancer prevention and adjuvant therapyBariatric surgery and cancer incidenceCachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapineCachexia-directed therapy (GDF-15 blockade)Chronotherapy: timing treatment to the body clockCoffee and tea intakeDietary fibre and the gut microbiome for immunotherapy responseDietary supplements during cancer treatment: interactions and harmsDietitian-led weight-loss programmes in HR-positive breast cancerEnhanced recovery (ERAS) and perioperative nutritionEnteral and parenteral nutrition supportExercise & lifestyle oncologyExercise during chemotherapy and radiotherapyFaecal microbiota transplantation for PD-1 non-respondersFasting and fasting-mimicking diets around chemotherapyGLP-1 receptor agonists and obesity-related cancer riskImmunonutrition before cancer surgeryKetogenic diets in glioblastomaMediterranean and plant-forward dietary patternsMetabolic therapy: starving the tumour of a nutrientMicrobiome modulation to unlock immunotherapyNutrition support and cachexia managementOncology nutrition assessment and medical nutrition therapyPrehabilitation before cancer surgeryProbiotics, antibiotics and stewardship around immunotherapyRed and processed meat reductionResistance training and protein for cachexia and sarcopeniaSleep and circadian interventions in cancerSmoking cessation in cancer patientsSoy foods and breast cancerStructured exercise programmes after curative treatmentTime-restricted eating in cancer prevention and survivorshipUltra-processed food and sugar-sweetened drinksVitamin D and omega-3 supplementation

institutions

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trials

14

ideas

11

key papers

3