Exercise & lifestyle oncology
Structured exercise during and after treatment, which the CHALLENGE trial showed improves survival in colon cancer.
The CHALLENGE trial (NEJM 2025) randomised colon cancer survivors to a structured exercise programme and showed improved disease-free and overall survival, the first level-1 evidence that exercise changes cancer outcomes. Exercise also reduces fatigue, cardiotoxicity, and chemotherapy-induced neuropathy.
How it works
Aerobic and resistance training modulate insulin, inflammation, and immune function.
- Cheap, safe, patient-controlled
- Delivery and adherence at scale
Latest papers
topQuery for this technology: (TITLE:"exercise oncology" OR ABSTRACT:"exercise oncology" OR TITLE:"exercise intervention" OR ABSTRACT:"exercise intervention") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma) AND survival. Results are unfiltered search hits about Exercise & lifestyle oncology, not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyGeriatric assessment
Shares Virginia Sun, European Society for Clinical Nutrition and Metabolism, Wilmot Cancer Institute, University of Rochester, Catch wasting early with a smart scale and a step counter.
- TermEnergy balance
Shares MET-hours per week, A dose-finding trial for exercise after cancer, BWEL (Breast Cancer Weight Loss, Alliance A011401), CHALLENGE (CCTG CO.21).
- TechnologyCardio-oncology
Shares Cancer neuroscience: cutting the nerve supply, A survivorship research endowment funded by a levy on curative therapy prices, A dedicated programme for cachexia and treatment toxicity research, Multinational Association of Supportive Care in Cancer.
- TechnologyCachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine
Shares Qualify a physical function endpoint so anti-wasting drugs can be approved, Treat cachexia as a disease: GDF-15 blockade plus anabolic and nutrition bundles, Get the one approved appetite drug licensed beyond a single country, Cachexia-directed therapy (GDF-15 blockade).
- TrialPonsegromab phase 2 in cancer cachexia
Shares Treat cachexia before it starts, Combine the new anti-wasting antibody with exercise and protein, Cachexia-directed therapy (GDF-15 blockade), Cancer cachexia.
- TrialROMANA 1 and ROMANA 2
Shares Qualify a physical function endpoint so anti-wasting drugs can be approved, Get the one approved appetite drug licensed beyond a single country, Cachexia-directed therapy (GDF-15 blockade), Cancer cachexia.
- TermBody composition (lean mass, fat mass, visceral fat)
Shares Read muscle loss automatically from scans patients already have, Exercise during chemotherapy and radiotherapy, Resistance training and protein for cachexia and sarcopenia, Dietitian-led weight-loss programmes in HR-positive breast cancer.
- IdeaTreat insomnia in survivors and measure whether the cancer notices
Shares Sleep and circadian interventions in cancer, Structured exercise programmes after curative treatment, Survivorship care and late-effects surveillance, Survivorship and late effects are neglected.