OnCo

Patent and exclusivity expiry

26 products with a sourced exclusivity floor or recorded entrants. 11 lose a key patent or regulatory exclusivity between 2026 and 2030, and 10 already face launched biosimilars or generics. Bars end at the expiry year; markers are entrants. Filter by modality, company and region.

26 products
Product
20262028203020322034203620382040
Rituxan / MabThera (and biosimilars)
Rituximab · Antibody · Roche / Genentech
US patent expired 20163 biosimilars since 2019
EU patent expired 20131 biosimilar since 2017
Herceptin (and biosimilars, Phesgo with pertuzumab)
Trastuzumab · Antibody · Roche / Genentech
US patent expired 20193 biosimilars since 2019
EU patent expired 20141 biosimilar since 2018
Avastin (and biosimilars)
Bevacizumab · Antibody · Roche / Genentech
US patent expired 20192 biosimilars since 2019
EU patent expired 20221 biosimilar since 2018
Yervoy
Ipilimumab · Antibody · Bristol Myers Squibb
US patent expired 2025
Keytruda / Keytruda Qlex (SC)
Pembrolizumab · Antibody · Merck & Co. (MSD)
EU reg. expired 2025
Opdivo / Opdivo Qvantig (SC)
Nivolumab · Antibody · Bristol Myers Squibb
Xtandi
Enzalutamide · Small molecule · Astellas, Pfizer (incl. Seagen)
Revlimid
Lenalidomide · Degrader or glue · Bristol Myers Squibb
1 generic since 2022
1 generic since 2022
Pluvicto
Lutetium-177 vipivotide tetraxetan · Radiopharmaceutical · Novartis
Ibrance
Palbociclib · Small molecule · Pfizer (incl. Seagen)
Tecentriq / Tecentriq Hybreza (SC)
Atezolizumab · Antibody · Roche / Genentech
Jakafi / Jakavi
Ruxolitinib · Small molecule · Incyte, Novartis
Yescarta
Axicabtagene ciloleucel · Cell therapy · Gilead Sciences (incl. Kite)
Imfinzi
Durvalumab · Antibody · AstraZeneca
Kymriah
Tisagenlecleucel · Cell therapy · Novartis
Cabometyx
Cabozantinib · Small molecule · Exelixis, Ipsen
Padcev
Enfortumab vedotin · ADC · Astellas, Generate:Biomedicines, Pfizer (incl. Seagen)
Trodelvy
Sacituzumab govitecan · ADC · Gilead Sciences (incl. Kite)
Enhertu
Trastuzumab deruxtecan · ADC · AstraZeneca, Daiichi Sankyo
Tagrisso
Osimertinib · Small molecule · AstraZeneca
Zytiga (generic)
Abiraterone acetate · Small molecule · Johnson & Johnson
1 generic since 2018
Velcade
Bortezomib · Small molecule · Johnson & Johnson, Takeda
1 generic since 2022
Gleevec
Imatinib · Small molecule · Novartis
1 generic since 2016
Alimta (and generics)
Pemetrexed · Chemotherapy
1 generic since 2022
Pomalyst / Imnovid
Pomalidomide · Degrader or glue · Bristol Myers Squibb
Sutent
Sunitinib · Small molecule · Pfizer (incl. Seagen)
1 generic since 2021
Patent floor (solid)Regulatory exclusivity (striped)Entrant launched or approvedEntrant in phase 3, filed or settledLanes: USEUJP

Floors, not forecasts

The patent year is the expiry of the key compound or composition patent as the marketing company discloses it, including supplementary protection certificates and patent term extensions where stated. Later formulation, method-of-use and manufacturing patents often extend practical exclusivity, and litigation or settlements can move entry earlier or later. Treat every bar as the earliest date competition could arrive, not the date it will.

Regulatory exclusivity is deterministic: 12 years from first US licensure for biologics (the Purple Book), 5 years for new chemical entities (the Orange Book), and 8 plus 2 years in the EU. It is the floor beneath the patent floor.

Why this matters

Loss of exclusivity is what turns a list price into a generic price and what forces the next generation of products to launch on time. The US paying-for-care and NHS pages show what each product costs today; this page says how long that lasts.

Add a product in src/data/exclusivity.ts with the 10-K, annual report or regulator page as the source. Products with no public disclosure are left out rather than guessed.