OnCo
drugsProductApproved2011🇪🇺🇬🇧🇯🇵🇨🇳🇦🇺

Abiraterone acetate

Abiraterone is a pill that shuts down testosterone production everywhere, including inside the tumour. Discovered at the Institute of Cancer Research, now generic and used from the first metastatic diagnosis.

COU-AA-301/302 (mCRPC post- and pre-docetaxel), LATITUDE and STAMPEDE (mHSPC, OS benefit), PEACE-1 (triplet with docetaxel). Given with prednisone. Generic since 2018-19; backbone partner for PARP inhibitors (PROpel, MAGNITUDE), capivasertib (CAPItello-281), and Pluvicto (PSMAddition).

Loading structure…
|
Abiraterone
PubChem
Modality
Small-molecule CYP17A1 inhibitor
Mechanism
Irreversible CYP17A1 (17α-hydroxylase/17,20-lyase) inhibition blocks adrenal and intratumoural androgen synthesis.
Brand / code
Zytiga (generic)
Medicare
Part D (self-administered)

Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026). Generic abiraterone (since 2018) is inexpensive; the Yonsa formulation and brand Zytiga cost far more.

Commercial insurance
covered on label

Multi-source generic on low-cost tiers; usually no prior authorisation. Cash prices without insurance are modest. Many plans require generic abiraterone before enzalutamide or other novel hormonal agents.

Assistance programmes

Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.

NICE recommendedNICE TA259 · 2012SMC: accepted
Appraised for
Metastatic castration-resistant prostate cancer after docetaxel
Notes
Before chemotherapy: TA387 (2016). Newly diagnosed high-risk hormone-sensitive disease (STAMPEDE/LATITUDE) was not recommended in TA721 (2021), but abiraterone went generic in 2022 and NHS England commissioned it for mHSPC via national policy.
NHS England
Routinely funded for the appraised indication (or via managed access)

Sources: NICE TA259 · SMC advice: abiraterone. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.

Regulatory

3top

Approvals

RegionYearIndication
US2011mCRPC after docetaxel
US2012mCRPC pre-chemotherapy
US2018High-risk mHSPC (LATITUDE)

Trials

top
ClinicalTrials.gov · phase 2/3
refreshed 2026-09-09
219 studies19 recruiting75 Phase 227 Phase 3
Search “Abiraterone acetate” on ClinicalTrials.gov →
Counts are from a name search and may include unrelated studies; up to 100 studies are summarised.

Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
Abiraterone acetate
intervention: Abiraterone acetate
Open on ClinicalTrials.gov →

Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.

Landmark trials in OnCo

Latest papers

top
Literature trend757 papers in the last 12 months-3% vs prior 12How this is computed
Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"Abiraterone acetate" OR ABSTRACT:"Abiraterone acetate" OR TITLE:"Zytiga" OR ABSTRACT:"Zytiga" OR TITLE:"generic" OR ABSTRACT:"generic") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Abiraterone acetate, not a curated reading list.

Connected

23top

Pages like this

not linked directly; found by shared links