Prednisone
Prednisone is the everyday steroid tablet in cancer care. It is the P in CHOP and MOPP for lymphoma, part of childhood leukaemia treatment, and taken with abiraterone in prostate cancer.
Overview
Prednisone was approved in 1955 and its label lists leukaemias and lymphomas for palliative management and hypercalcaemia of malignancy alongside many inflammatory conditions. In oncology it is a component of R-CHOP (diffuse large B-cell lymphoma), MOPP and BEACOPP (Hodgkin lymphoma), childhood and adult ALL induction and CLL regimens, and it is co-prescribed with abiraterone to prevent mineralocorticoid excess and with docetaxel in metastatic castration-resistant prostate cancer. It also treats immune-related adverse events of checkpoint inhibitors and is used in palliative care for appetite and fatigue. Prednisolone is the equivalent used in the UK and much of Europe. Long-term use brings hyperglycaemia, osteoporosis, infection risk, mood change and adrenal suppression.
- AmivantamabApproved
- CamizestrantApproved
- Comprehensive genomic profilingStandard of care
- Liquid biopsy (ctDNA)Standard of care
- LorlatinibApproved
- MRD / molecular residual disease testingEstablished
- ADC payload neutralisersPhase 1
- BGB-16673Phase 3
- Bispecific ADCPhase 3
- BRUIN CLL-321Positive
- CaDAnCe-304Recruiting
- CIRCULATE-Japan (GALAXY / VEGA / ALTAIR)Active
- A clone report from blood at every treatment cycle
- A fast route to the matched drug when it is licensed for another cancer
- A multi-cancer platform trial of adaptive (dose-holiday) therapy
- A national rapid research autopsy network for end-stage cancer
- A standard evolvability score for every tumour
- A standing platform trial that assigns treatment by how the tumour escaped
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance atlas: how tumours escape and what closes the route · Lines of therapy.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1955 | Palliative management of leukaemias and lymphomas; hypercalcaemia of malignancy; inflammatory conditions |
Safety
topTrials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Prednisone" OR ABSTRACT:"Prednisone" OR TITLE:"Deltasone" OR ABSTRACT:"Deltasone" OR TITLE:"historic" OR ABSTRACT:"historic" OR TITLE:"Rayos" OR ABSTRACT:"Rayos" OR TITLE:"Prednisolone active metabolite, used in the UK and Europe" OR ABSTRACT:"Prednisolone active metabolite, used in the UK and Europe") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Prednisone, not a curated reading list.
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