Loading
Lymphoma treatment is written in acronyms, one letter per drug. This entry spells out the ones a patient will see on a chart or a consent form, and says which disease each belongs to.
Each acronym is a fixed recipe of drugs given on a fixed schedule, usually in three- or four-week cycles.
Aggressive B-cell lymphoma. R-CHOP is rituximab, cyclophosphamide, doxorubicin (hydroxydaunorubicin), vincristine (Oncovin) and prednisolone, every 21 days. Pola-R-CHP swaps vincristine for polatuzumab vedotin. DA-EPOCH-R adds etoposide and gives the cyclophosphamide, doxorubicin and etoposide as a 96-hour infusion with the dose adjusted upward or downward by the neutrophil count in the previous cycle. Salvage regimens before a transplant are R-ICE (ifosfamide, carboplatin, etoposide), R-DHAP (dexamethasone, high-dose cytarabine, cisplatin) and R-GDP (gemcitabine, dexamethasone, cisplatin); R-GemOx (gemcitabine and oxaliplatin) is the gentler outpatient option for people who will never have a transplant.
Burkitt and high-grade disease. CODOX-M/IVAC alternates cyclophosphamide, vincristine, doxorubicin and high-dose methotrexate with ifosfamide, etoposide and high-dose cytarabine. Hyper-CVAD alternates part A (cyclophosphamide, vincristine, doxorubicin, dexamethasone) with part B (high-dose methotrexate and cytarabine). Both are intensive and inpatient; DA-EPOCH-R is the outpatient alternative.
Brain. MATRix is methotrexate, cytarabine, thiotepa and rituximab.
Indolent B-cell. BR is bendamustine and rituximab. R-CVP replaces the doxorubicin of R-CHOP with nothing and keeps cyclophosphamide, vincristine and prednisolone. R-squared, written R2, is rituximab and lenalidomide with no chemotherapy at all.
Mantle cell. VR-CAP substitutes bortezomib for vincristine. The Nordic and European young-patient regimens alternate R-CHOP with R-DHAP or use R-maxi-CHOP with high-dose cytarabine before an autologous transplant.
Hodgkin lymphoma. ABVD is doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine. AVD is ABVD without the bleomycin. A+AVD adds brentuximab vedotin, N-AVD adds nivolumab. Escalated BEACOPP is bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisolone at increased doses; BrECADD replaces the bleomycin, vincristine and procarbazine with brentuximab vedotin and dacarbazine.
T-cell. CHOP is R-CHOP without the rituximab, because T cells do not carry CD20. CHOEP adds etoposide. A+CHP replaces vincristine with brentuximab vedotin. SMILE is dexamethasone (steroid), methotrexate, ifosfamide, L-asparaginase and etoposide, for extranodal NK/T-cell lymphoma.
Backbone ribbon from PDB 6VJA. RCSB PDB 6VJA. The ribbon widens where the chain is folded into a regular pattern and narrows where it is a loose loop.
Showing the molecule this term concerns: Rituximab.
Shares ABVD, BEACOPP and BrECADD (Hodgkin lymphoma regimens), Procarbazine, Early-stage classical Hodgkin lymphoma (stage I to II), Relapsed and refractory classical Hodgkin lymphoma.
Shares Nodal T-follicular helper cell lymphoma, angioimmunoblastic type (angioimmunoblastic T-cell lymphoma), Thiotepa, Early-stage classical Hodgkin lymphoma (stage I to II), Relapsed and refractory classical Hodgkin lymphoma.
Shares Procarbazine, Nodular lymphocyte-predominant Hodgkin lymphoma (nodular lymphocyte-predominant B-cell lymphoma), Dacarbazine, Bleomycin.
Shares Cytarabine, Ifosfamide, Methotrexate, Prednisone.
Shares Nodular lymphocyte-predominant Hodgkin lymphoma (nodular lymphocyte-predominant B-cell lymphoma), Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Primary mediastinal (thymic) large B-cell lymphoma.
Shares Polatuzumab vedotin, Early-stage classical Hodgkin lymphoma (stage I to II), Relapsed and refractory classical Hodgkin lymphoma, Brentuximab vedotin.
Shares Polatuzumab vedotin, Early-stage classical Hodgkin lymphoma (stage I to II), Relapsed and refractory classical Hodgkin lymphoma, Brentuximab vedotin.
Shares Bleomycin, Brentuximab vedotin, Advanced-stage classical Hodgkin lymphoma (stage III to IV), Prednisone.