Procarbazine
Procarbazine (Matulane) is an old chemotherapy capsule from the MOPP regimen for Hodgkin lymphoma; it is now used mainly in the PCV combination for certain brain tumours.
Overview
Procarbazine was approved in 1969 for stage III and IV Hodgkin disease as part of MOPP (nitrogen mustard, vincristine, procarbazine, prednisone) and later BEACOPP; ABVD replaced MOPP because procarbazine causes permanent infertility in men and secondary leukaemia. Its major contemporary role is off label in PCV (procarbazine, lomustine, vincristine), which with radiotherapy roughly doubled survival in 1p/19q-codeleted oligodendroglioma (RTOG 9402, EORTC 26951). Patients must avoid tyramine-rich foods, alcohol and sympathomimetics because of monoamine oxidase inhibition; nausea and myelosuppression are common.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1969 | Stage III and IV Hodgkin disease in combination (MOPP) |
Trials
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Latest papers
topQuery for this drug: (TITLE:"Procarbazine" OR ABSTRACT:"Procarbazine" OR TITLE:"Matulane" OR ABSTRACT:"Matulane" OR TITLE:"Natulan" OR ABSTRACT:"Natulan") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Procarbazine, not a curated reading list.
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