EORTC 26951: adjuvant PCV after radiotherapy for anaplastic oligodendroglial tumours, long-term follow-up
This European trial confirmed, independently of the American RTOG 9402 study, that PCV chemotherapy added to radiotherapy lengthens survival in anaplastic oligodendroglioma, with the largest benefit in tumours carrying the 1p/19q codeletion.
Overview
Phase 3 trial of 368 patients with anaplastic oligodendroglial tumours randomised to radiotherapy alone or radiotherapy followed by six cycles of PCV, reported at a median follow-up of 140 months.
Median overall survival was 42.3 months with PCV against 30.6 months without (hazard ratio 0.75); in the 80 patients with 1p/19q codeletion median survival was not reached with PCV against 112 months without (hazard ratio 0.56), and IDH mutation and MGMT methylation were also prognostic.
- Median overall survival 42.3 vs 30.6 months overall; hazard ratio 0.75.
- 1p/19q-codeleted: median survival not reached vs 112 months; hazard ratio 0.56.
Together with RTOG 9402, this trial made radiotherapy followed by PCV the standard for 1p/19q-codeleted anaplastic oligodendroglioma; the CODEL trial is now comparing PCV with temozolomide.
- Codeleted subgroup was small.
- About a third of patients did not complete PCV because of toxicity.
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