RTOG 9402
RTOG 9402 looked negative at first and then, with long follow-up, showed that adding PCV chemotherapy to radiotherapy doubles survival in oligodendrogliomas with 1p/19q co-deletion, from about seven to fourteen years.
Overview
RTOG 9402 randomised 291 patients with anaplastic oligodendroglial tumours to four cycles of intensive procarbazine, lomustine and vincristine (PCV) followed by radiotherapy, or radiotherapy alone. Overall survival in the whole group did not differ at first, but in the 1p/19q co-deleted subgroup median survival was 14.7 years with PCV plus radiotherapy versus 7.3 years with radiotherapy alone (Cairncross and colleagues, Journal of Clinical Oncology 2013), a result mirrored by EORTC 26951. Chemoradiation with PCV became standard for co-deleted tumours, and the molecular marker entered the WHO classification.
- PCV then radiotherapy: 14.7 years; Radiotherapy alone: 7.3 years.
- Overall survival counts deaths from any cause, so it is the most direct measure of whether a treatment helps people live longer.
- These results apply to the people the trial enrolled: Anaplastic oligodendroglioma and oligoastrocytoma: PCV chemotherapy before radiotherapy versus radiotherapy alone. People in a different situation may not see the same effect.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
291 participants enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Median overall survival, 1p/19q co-deletedprimary | PCV then radiotherapy | 59 | 14.7 years | - | - | - |
| Radiotherapy alone | 67 | 7.3 years |
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