Dacarbazine
Dacarbazine is an older chemotherapy infusion. It was the standard treatment for advanced melanoma for decades and is the D in the ABVD regimen that cures most Hodgkin lymphoma.
Overview
Dacarbazine was approved in 1975 for metastatic malignant melanoma and as second-line therapy with other agents for Hodgkin disease. In melanoma it produced responses in roughly one patient in ten and was the control arm in the trials that established ipilimumab, vemurafenib and dabrafenib, after which it left routine use. In Hodgkin lymphoma it remains essential as part of ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) and its brentuximab vedotin variant A+AVD. It is strongly emetogenic, causes a flu-like syndrome and photosensitivity, and is hepatotoxic, with rare hepatic vein thrombosis.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1975 | Metastatic malignant melanoma; Hodgkin disease (second line, combination) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Dacarbazine" OR ABSTRACT:"Dacarbazine" OR TITLE:"DTIC-Dome" OR ABSTRACT:"DTIC-Dome" OR TITLE:"historic" OR ABSTRACT:"historic" OR TITLE:"DTIC" OR ABSTRACT:"DTIC") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Dacarbazine, not a curated reading list.
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