Carmustine
Carmustine is a chemotherapy that reaches the brain. It is given by infusion for brain tumours, lymphoma and myeloma, and as a slow-release wafer left in the cavity after a brain tumour is removed.
Overview
Intravenous carmustine (BiCNU, approved 1977) is indicated as palliative therapy, alone or in combination, for brain tumours (glioblastoma, brainstem glioma, medulloblastoma, astrocytoma, ependymoma and metastatic brain tumours), multiple myeloma with prednisone, and relapsed or refractory Hodgkin and non-Hodgkin lymphoma; it is also part of the BEAM conditioning regimen before autologous transplant in lymphoma. The Gliadel wafer (approved 1996 for recurrent glioblastoma, 2003 for newly diagnosed high-grade glioma) is a biodegradable polifeprosan 20 implant placed in the resection cavity; the pivotal 240-patient placebo-controlled trial in newly diagnosed high-grade glioma showed a modest survival benefit. Delayed cumulative myelosuppression and dose-related pulmonary fibrosis limit lifetime dosing.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1977 | Brain tumours, multiple myeloma, relapsed Hodgkin and non-Hodgkin lymphoma (BiCNU) |
| US | 1996 | Recurrent glioblastoma as an adjunct to surgery (Gliadel Wafer); newly diagnosed high-grade glioma with surgery and radiation added 2003 |
Trials
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Latest papers
topQuery for this drug: (TITLE:"Carmustine" OR ABSTRACT:"Carmustine" OR TITLE:"BiCNU" OR ABSTRACT:"BiCNU" OR TITLE:"Gliadel Wafer" OR ABSTRACT:"Gliadel Wafer" OR TITLE:"BCNU" OR ABSTRACT:"BCNU" OR TITLE:"Carmustine implant" OR ABSTRACT:"Carmustine implant") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Carmustine, not a curated reading list.
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