Cytarabine
Cytarabine is the core chemotherapy for acute myeloid leukaemia, given with an anthracycline as the classic 7+3 induction and at high doses for consolidation; it is also injected into the spinal fluid to treat or prevent leukaemia in the brain.
Overview
Cytarabine was approved in 1969 and remains, with an anthracycline, the remission-induction standard in acute non-lymphocytic leukaemia of adults and children; the label also covers acute lymphocytic leukaemia and blast-phase CML, and intrathecal use for prophylaxis and treatment of meningeal leukaemia. High-dose cytarabine consolidation (CALGB 8525) defined post-remission therapy for favourable-risk AML, and it partners fludarabine (FLAG), cladribine and midostaurin, gemtuzumab or venetoclax in modern regimens. A liposomal co-formulation with daunorubicin (CPX-351, Vyxeos) has its own record. Cerebellar toxicity at high doses, conjunctivitis (steroid eye drops) and profound myelosuppression are characteristic.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1969 | Remission induction in acute non-lymphocytic leukaemia; ALL; blast-phase CML; intrathecal therapy of meningeal leukaemia |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Cytarabine" OR ABSTRACT:"Cytarabine" OR TITLE:"Cytosar-U" OR ABSTRACT:"Cytosar-U" OR TITLE:"historic" OR ABSTRACT:"historic" OR TITLE:"Ara-C" OR ABSTRACT:"Ara-C" OR TITLE:"Cytosine arabinoside" OR ABSTRACT:"Cytosine arabinoside" OR TITLE:"DepoCyt liposomal, discontinued" OR ABSTRACT:"DepoCyt liposomal, discontinued") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cytarabine, not a curated reading list.
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