Thioguanine
Thioguanine (Tabloid) is an oral chemotherapy tablet used in some regimens to induce and consolidate remission in acute myeloid leukaemia; long-term use is avoided because it damages the liver.
Overview
Thioguanine, a sibling of mercaptopurine from the Elion-Hitchings programme, was approved in 1966 for remission induction and consolidation of acute non-lymphocytic leukaemias. It appears in historical AML regimens such as DAT and TAD and in some childhood ALL protocols, but the label advises against maintenance or long-term use because of hepatic sinusoidal obstruction syndrome and nodular regenerative hyperplasia; the UK ALL97 trial confirmed excess liver toxicity when it replaced mercaptopurine in maintenance. Myelosuppression is dose-limiting, and TPMT-deficient patients need dose reduction.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1966 | Remission induction and consolidation of acute non-lymphocytic leukaemias |
Trials
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Latest papers
topQuery for this drug: (TITLE:"Thioguanine" OR ABSTRACT:"Thioguanine" OR TITLE:"Tabloid" OR ABSTRACT:"Tabloid" OR TITLE:"6-TG" OR ABSTRACT:"6-TG" OR TITLE:"Tioguanine" OR ABSTRACT:"Tioguanine") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Thioguanine, not a curated reading list.
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