Daunorubicin
Daunorubicin is the anthracycline most often combined with cytarabine to bring acute myeloid leukaemia into remission; it is also part of induction for acute lymphoblastic leukaemia.
Overview
Daunorubicin, isolated from Streptomyces in the 1960s, was approved in 1979 for remission induction in acute non-lymphocytic leukaemia in adults and in acute lymphocytic leukaemia in adults and children, in combination with other agents. With cytarabine it forms the 7+3 regimen that has anchored AML induction for fifty years; the label reports complete remission rates of 53 to 65% for the combination. A liposomal fixed-ratio co-formulation with cytarabine (CPX-351, Vyxeos, 2017) improved survival in secondary AML and has its own record. Cumulative dose-dependent cardiomyopathy limits lifetime exposure, and extravasation causes severe tissue necrosis.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1979 | Remission induction in acute non-lymphocytic leukaemia (adults) and acute lymphocytic leukaemia (adults and children), in combination |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Daunorubicin" OR ABSTRACT:"Daunorubicin" OR TITLE:"Cerubidine" OR ABSTRACT:"Cerubidine" OR TITLE:"historic" OR ABSTRACT:"historic" OR TITLE:"Daunomycin" OR ABSTRACT:"Daunomycin" OR TITLE:"Rubidomycin" OR ABSTRACT:"Rubidomycin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Daunorubicin, not a curated reading list.
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