Epirubicin
Epirubicin (Ellence) is a close relative of doxorubicin used mainly after breast cancer surgery when lymph nodes are involved, and in stomach cancer regimens; it is a little kinder to the heart.
Overview
Epirubicin was approved by the FDA in 1999 as a component of adjuvant therapy for axillary node-positive breast cancer, based on the Canadian MA.5 (CEF versus CMF) and French FASG trials in which epirubicin-containing regimens improved relapse-free and overall survival. Outside the US it has been used far more widely since the 1980s, including in the ECF/EOX regimens for gastro-oesophageal cancer (REAL-2) and in FEC-docetaxel sequences for breast cancer. Cardiotoxicity is cumulative-dose dependent (the label caps lifetime exposure at 900 mg/m2), secondary acute myeloid leukaemia is a recognised late effect, and it is a vesicant.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1999 | Adjuvant therapy for axillary node-positive breast cancer |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Epirubicin" OR ABSTRACT:"Epirubicin" OR TITLE:"Ellence" OR ABSTRACT:"Ellence" OR TITLE:"Pharmorubicin" OR ABSTRACT:"Pharmorubicin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Epirubicin, not a curated reading list.
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