Idarubicin
Idarubicin is the anthracycline many centres prefer with cytarabine to induce remission in adult acute myeloid leukaemia.
Overview
Idarubicin was approved in 1990 for adult acute myeloid leukaemia as part of combination induction. Four randomised trials totalling 823 newly diagnosed patients (Memorial Sloan Kettering, Southeastern Cancer Study Group, US multicentre and GIMEMA) compared idarubicin with daunorubicin, each with cytarabine, and showed higher complete remission rates and, in some, longer survival with idarubicin; it is a standard induction anthracycline (for example in the 3+7 and the FLAG-Ida salvage regimens) and in acute promyelocytic leukaemia protocols with all-trans retinoic acid. Cardiotoxicity, severe myelosuppression and extravasation injury are the class risks.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1990 | Adult acute myeloid leukaemia, as a component of combination induction chemotherapy |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Idarubicin" OR ABSTRACT:"Idarubicin" OR TITLE:"Idamycin PFS" OR ABSTRACT:"Idamycin PFS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Idarubicin, not a curated reading list.
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