Pentostatin
An intravenous drug given every other week that produces long remissions in hairy cell leukaemia by poisoning the leukaemic lymphocytes' purine metabolism; cladribine is the one-week alternative.
Overview
Pentostatin was approved in the United States in 1991 for hairy cell leukaemia, initially after interferon alfa had failed and then as first-line treatment, on the strength of a randomised comparison in which it produced far more complete remissions than interferon (Grever, JCO 1995). It is given as a short intravenous infusion of 4 mg/m² every other week until maximal response. It is also used in T-cell leukaemias and lymphomas and, off label, in graft-versus-host disease and reduced-intensity transplant conditioning. Prolonged lymphopenia with infection risk is the main toxicity, and renal impairment requires dose reduction.
Binds adenosine deaminase almost irreversibly, so deoxyadenosine triphosphate accumulates in lymphocytes, blocks DNA synthesis and triggers apoptosis. Connects to Adenosine deaminase (ADA).
1.Pentostatin slips into a pocket on Adenosine deaminase (ADA).
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1991 | Hairy cell leukaemia (initially alpha-interferon-refractory; later untreated disease) |
Trials
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Latest papers
topQuery for this drug: (TITLE:"Pentostatin" OR ABSTRACT:"Pentostatin" OR TITLE:"Nipent" OR ABSTRACT:"Nipent" OR TITLE:"Deoxycoformycin" OR ABSTRACT:"Deoxycoformycin" OR TITLE:"2'-deoxycoformycin" OR ABSTRACT:"2'-deoxycoformycin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Pentostatin, not a curated reading list.
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