ABVD
Checked 2026-09-09
Classical Hodgkin lymphoma: 2-4 cycles early stage (PET-adapted), 6 cycles advanced stage
One cycle
every 28 days × 2-6 · about 8 weeks in totalComponents
| Drug | Dose | Route | Days | Note |
|---|---|---|---|---|
Doxorubicin Cytotoxic chemotherapy (anthracycline) | 25 mg/m² | IV | D1, 15 | |
Bleomycin Glycopeptide antibiotic (DNA-cleaving) | 10 units/m² | IV | D1, 15 | |
Vinblastine Vinca alkaloid (microtubule inhibitor) | 6 mg/m² | IV | D1, 15 | |
Dacarbazine | 375 mg/m² | IV | D1, 15 |
Cycles
2-6
28-day cycle
Emetogenicity
High (>90%)
G-CSF
Not routine
Notes
- RATHL: drop bleomycin after a negative interim PET (AVD) with no loss of efficacy.
- Give on schedule regardless of neutrophil count; G-CSF increases bleomycin lung toxicity.
Used in
Trials
Products
Source
RATHL, NEJM 2016 (PET-adapted omission of bleomycin)
Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.