Thiotepa
Thiotepa is an old chemotherapy with a modern job: at high doses it prepares patients for stem cell transplants, and it is still instilled into the bladder or body cavities for superficial bladder cancer and malignant effusions.
Overview
Thiotepa was first approved in 1959 for adenocarcinoma of the breast or ovary, superficial papillary carcinoma of the urinary bladder and control of malignant intracavitary effusions. Tepadina (approved 2017 in the US, 2010 in the EU) added conditioning before allogeneic haematopoietic stem cell transplantation, initially for children with class 3 beta-thalassaemia in the US and, in the EU, for haematological and solid tumours in adults and children. In practice thiotepa-based regimens (TBC, thiotepa-busulfan-fludarabine) are standard before autologous transplant in primary CNS lymphoma and in cord blood and haploidentical transplantation. Profound myelosuppression, mucositis and skin toxicity from sweat excretion (patients bathe frequently) are the main issues.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1959 | Breast and ovarian adenocarcinoma; superficial papillary bladder carcinoma (intravesical); malignant effusions |
| US | 2017 | Conditioning before allogeneic HSCT for class 3 beta-thalassaemia in children (Tepadina) |
| EU | 2010 | Conditioning before haematopoietic progenitor cell transplantation for haematological diseases and solid tumours (Tepadina) |
Trials
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Latest papers
topQuery for this drug: (TITLE:"Thiotepa" OR ABSTRACT:"Thiotepa" OR TITLE:"Tepadina" OR ABSTRACT:"Tepadina" OR TITLE:"Thioplex historic" OR ABSTRACT:"Thioplex historic" OR TITLE:"Triethylenethiophosphoramide" OR ABSTRACT:"Triethylenethiophosphoramide") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Thiotepa, not a curated reading list.
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