Zoledronic acid
Zoledronic acid (Zometa) is a fifteen-minute infusion given every few weeks or months to strengthen bone and prevent fractures, spinal cord compression and the need for radiotherapy in people with myeloma or cancer that has spread to bone; it also treats dangerously high calcium caused by cancer.
Overview
Zoledronic acid was approved by the FDA in August 2001 for hypercalcaemia of malignancy (two randomised trials against pamidronate showed faster and more complete normalisation of calcium) and in 2002 for multiple myeloma and bone metastases from solid tumours in conjunction with antineoplastic therapy, on trials in breast cancer, prostate cancer, lung and other solid tumours that reduced skeletal-related events. The EU authorised Zometa in 2001. Every-12-week dosing was shown non-inferior to monthly (CALGB 70604), and adjuvant zoledronic acid reduces recurrence and death in postmenopausal early breast cancer (EBCTCG meta-analysis), an off-label but guideline-endorsed use. Osteonecrosis of the jaw, renal impairment (dose adjustment and creatinine monitoring) and acute-phase reactions after the first dose are the main risks. Denosumab is the alternative when renal function is poor.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2001 | Hypercalcaemia of malignancy |
| US | 2002 | Multiple myeloma and bone metastases from solid tumours, with antineoplastic therapy |
| EU | 2001 | Prevention of skeletal-related events in advanced malignancies involving bone; tumour-induced hypercalcaemia |
Trials
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Latest papers
topQuery for this drug: (TITLE:"Zoledronic acid" OR ABSTRACT:"Zoledronic acid" OR TITLE:"Zometa" OR ABSTRACT:"Zometa" OR TITLE:"Reclast / Aclasta osteoporosis formulation" OR ABSTRACT:"Reclast / Aclasta osteoporosis formulation" OR TITLE:"Zoledronate" OR ABSTRACT:"Zoledronate") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Zoledronic acid, not a curated reading list.
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