Granisetron
Granisetron is an anti-sickness medicine for chemotherapy given as a tablet, an injection, a week-long skin patch (Sancuso) or a slow-release injection that lasts several days (Sustol).
Overview
Granisetron (Kytril) was approved in December 1993 for prevention of nausea and vomiting from emetogenic chemotherapy, with tablets and a radiotherapy indication following; oral and intravenous granisetron are now generic. Two formulations extended its reach: the Sancuso transdermal patch (2008) applied 24 to 48 hours before chemotherapy and worn for up to seven days for regimens of up to five consecutive days, and Sustol (2016), a polymer-based extended-release subcutaneous injection that maintains levels for at least five days and is approved with other antiemetics for acute and delayed nausea and vomiting after moderately emetogenic or anthracycline-cyclophosphamide chemotherapy. The EU authorised Sancuso in 2012. Headache and constipation are the class effects; QT prolongation is less than with dolasetron.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1993 | Prevention of nausea and vomiting from emetogenic chemotherapy (Kytril; radiotherapy later) |
| US | 2008 | Transdermal system for chemotherapy of up to five consecutive days (Sancuso) |
| US | 2016 | Extended-release injection for acute and delayed nausea and vomiting with moderately emetogenic or anthracycline-cyclophosphamide chemotherapy (Sustol) |
| EU | 2012 | Transdermal granisetron for moderately or highly emetogenic chemotherapy (Sancuso) |
Trials
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Latest papers
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