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Published in the same issue as TAX 327 and reaching the same conclusion by a different route: docetaxel extends life in advanced prostate cancer. The extra drug it was paired with, estramustine, brought enough side effects that it was dropped from practice.
Daniel Petrylak and the Southwest Oncology Group randomised 770 men with metastatic androgen-independent prostate cancer to docetaxel with estramustine or to mitoxantrone with prednisone; 674 were eligible for analysis. Overall survival was the primary endpoint.
The pair of trials published in the New England Journal of Medicine on 7 October 2004 is the reason docetaxel became standard. TAX 327 gave the better toxicity profile and the schedule that survived; SWOG 9916 gave the independent replication. The estramustine combination produced more febrile neutropenia, more nausea and vomiting and more cardiovascular events, and did not deliver a better survival result, so the simpler regimen won.
The confirmatory half of the 2004 result. Two independent trials, two different docetaxel regimens, the same direction of effect: this is why docetaxel was adopted quickly and why it survived the move into hormone-sensitive disease a decade later.
Shares TAX 327: docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer, Mitoxantrone, Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs, Prednisone and the tag prostate-evidence.
Shares PSA (prostate-specific antigen), Castration-resistant prostate cancer (CRPC), Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Acquired resistance to every therapy and the tag prostate-evidence.
Shares PSA (prostate-specific antigen), Castration-resistant prostate cancer (CRPC), Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Acquired resistance to every therapy and the tag prostate-evidence.
Shares PSA (prostate-specific antigen), Castration-resistant prostate cancer (CRPC), Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Acquired resistance to every therapy and the tag prostate-evidence.
Shares PSA (prostate-specific antigen), Castration-resistant prostate cancer (CRPC), Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Acquired resistance to every therapy and the tag prostate-evidence.
Shares PSA (prostate-specific antigen), Castration-resistant prostate cancer (CRPC), Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Acquired resistance to every therapy and the tag prostate-evidence.
Shares Castration-resistant prostate cancer (CRPC), Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Acquired resistance to every therapy, Metastatic castration-resistant prostate cancer and the tag prostate-evidence.
Shares PSA (prostate-specific antigen), Castration-resistant prostate cancer (CRPC), Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Acquired resistance to every therapy and the tag prostate-evidence.