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Creatine helps athletes and older adults build strength alongside training. In people with cancer, trials found it did not improve weight loss and muscle wasting, did not add to resistance exercise in men on hormone therapy for prostate cancer, and did not improve muscle performance in breast cancer survivors. Exercise itself is what helps.
Memorial Sloan Kettering's About Herbs entry describes creatine as an effective aid to strength and muscle mass for athletes and people starting fitness programmes, and in older adults when combined with resistance training. In oncology settings the results are consistently negative: creatine did not improve cachexia, did not improve muscle mass or function in colorectal cancer, conferred no additional benefit on strength or physical function when added to resistance exercise in men with prostate cancer on androgen deprivation therapy, and did not affect muscular performance in breast cancer survivors. In mouse models creatine suppressed tumour growth in some studies but promoted colorectal and breast cancer metastasis in another. Side effects are gastrointestinal irritation, cramps, headache and weight gain from water retention. Structured resistance and aerobic exercise, with adequate protein, remains the intervention with evidence for muscle and function during and after treatment.
Raises muscle phosphocreatine stores to buffer energy during short intense effort; this aids training but has not changed cancer-related muscle wasting.
Query for this technology: (TITLE:"Creatine supplements" OR ABSTRACT:"Creatine supplements" OR TITLE:"Creatine monohydrate" OR ABSTRACT:"Creatine monohydrate") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Creatine supplements, not a curated reading list.
Shares Cancer cachexia, Evidence-based integrative oncology, Misinformation and unproven therapies, Colorectal cancer and the tags complementary, supportive-care.
Shares Exercise & lifestyle oncology, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies, Prostate cancer and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies, Prostate cancer and the tags complementary, supportive-care.
Shares Carnitine and acetyl-L-carnitine, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies, Prostate cancer and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
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