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Glucosamine, often with chondroitin, is one of the most used joint supplements. Most trials in osteoarthritis found no benefit and the American College of Rheumatology advises against it. Studies linking it to lower cancer risk are observational and may be biased. It can raise the blood-thinning effect of warfarin and affect blood sugar.
Memorial Sloan Kettering's About Herbs entry describes glucosamine as mostly studied in osteoarthritis: one large multicentre trial found glucosamine with chondroitin comparable to celecoxib for severe knee pain, but most other studies found no benefit for knee or hip osteoarthritis or back pain, and the American College of Rheumatology conditionally recommends against it, while a European guideline favours a prescription formulation not available in the United States. Glucosamine and chondroitin use has been correlated with lower cancer risk and mortality in observational studies, but MSK notes that bias could not be ruled out and confirmatory studies are needed; there is no trial evidence for any anticancer effect. For aromatase-inhibitor joint pain, acupuncture and exercise have better evidence. Safety: generally well tolerated, but glucosamine may potentiate warfarin and raise INR, inhibit platelet aggregation, worsen insulin resistance, raise intraocular pressure (shown in a randomised trial in older people) and cause liver injury in people with liver disease; it has been associated with higher cardiovascular risk in osteoarthritis. People allergic to shellfish should check the source.
A building block of cartilage glycosaminoglycans; oral supplements were expected to support cartilage repair, which trials have mostly not confirmed.
Query for this technology: (TITLE:"Glucosamine and chondroitin" OR ABSTRACT:"Glucosamine and chondroitin" OR TITLE:"Glucosamine sulfate" OR ABSTRACT:"Glucosamine sulfate" OR TITLE:"Chondroitin sulfate" OR ABSTRACT:"Chondroitin sulfate") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Glucosamine and chondroitin, not a curated reading list.
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Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
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