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Bromelain is an enzyme from pineapple stems used for swelling, pain and wound clean-up. In cancer the evidence is a mixed formula for aromatase-inhibitor joint pain and a single case report, so its anti-cancer claims are untested. It can cause allergic reactions and may increase bleeding with blood thinners.
Bromelain is a protein-digesting enzyme from pineapple stems. Memorial Sloan Kettering's About Herbs entry reports clinical evidence for a bromelain-based product in debriding burns and chronic wounds, small studies for postoperative pain and swelling, and mixed results for arthritis pain and inflammation. In cancer, a formulation of alpha-lipoic acid, boswellia, methylsulfonylmethane and bromelain improved aromatase-inhibitor joint symptoms in postmenopausal women with early breast cancer, which cannot be attributed to bromelain alone, and a case report described PSA reduction with bromelain alongside immunotherapy in prostate cancer. MSK states that well-designed randomised trials are needed to evaluate its anticancer potential. Allergic reactions are reported; it may increase bleeding with anticoagulants in preclinical studies, inhibits CYP2C9 in vitro and may raise blood levels of tetracycline antibiotics.
Cysteine proteases that break down fibrin and inflammatory mediators locally; how much intact enzyme is absorbed from the gut is uncertain.
Query for this technology: (TITLE:"Bromelain" OR ABSTRACT:"Bromelain" OR TITLE:"pineapple enzyme" OR ABSTRACT:"pineapple enzyme" OR TITLE:"Pineapple stem enzyme" OR ABSTRACT:"Pineapple stem enzyme" OR TITLE:"Ananas comosus protease" OR ABSTRACT:"Ananas comosus protease") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Bromelain (pineapple enzyme), not a curated reading list.
Shares Boswellia (frankincense) extracts, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Aromatase inhibitor, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
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