Shared concurrent control arms across sponsors' trials in the same setting
When five companies each run a trial against the same standard treatment in the same patients, let them pool the standard-treatment patients so fewer people are randomised to the old drug.
Concurrent trials in the same indication each recruit their own control arm on identical standard of care. A pre-agreed common data model, shared eligibility core and a neutral data custodian would let sponsors borrow concurrent (not historical) controls with regulatory pre-agreement, as pioneered by the Alzheimer's Disease EPOCH and the Bayesian borrowing frameworks in paediatric oncology.
- Too many combinations to test · There are thousands of possible drug pairs and sequences. Trials can test a few dozen a year.
- Trials enrol too few, too slowly · Fewer than one in ten adults with cancer joins a trial. Trials close for lack of patients, not lack of ideas.
Pages like this
not linked directly; found by shared links- IdeaA standing platform trial for every major cancer, funded as infrastructure
Shares Basket, umbrella, and platform trials, Too many combinations to test, Trials enrol too few, too slowly, Pancreatic ductal adenocarcinoma.
- IdeaOne ethics approval and one consent form for a platform trial across countries
Shares ClinicalTrials.gov, Basket, umbrella, and platform trials, Too many combinations to test.
- IdeaCompeting sponsors share one control arm in the same indication
Shares Basket, umbrella, and platform trials, Trials enrol too few, too slowly, Pancreatic ductal adenocarcinoma.
- IdeaA perpetual platform trial in every major cancer, funded as infrastructure
Shares Basket, umbrella, and platform trials, Too many combinations to test, Bladder & urothelial cancer, Pancreatic ductal adenocarcinoma.
- IdeaPublish why patients were screened out of each trial
Shares ClinicalTrials.gov, Trials enrol too few, too slowly.
- IdeaOne clinical trial application accepted by regulators in every major region
Shares ClinicalTrials.gov, Trials enrol too few, too slowly.
- IdeaAn open forecasting tournament on which combination trials will succeed
- IdeaBorrow from past control arms to shrink the control group in phase 3