Fedratinib
A second JAK inhibitor for myelofibrosis that works after ruxolitinib fails; it carries a boxed warning for a rare brain toxicity (Wernicke encephalopathy) so thiamine is checked.
JAKARTA (first line) and JAKARTA-2 (post-ruxolitinib) showed spleen responses in ~35-45%. Development was halted in 2013 over encephalopathy cases and resumed after review; approved 2019 with thiamine monitoring.
- Medicare
- Part D (self-administered)
Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026).
- Commercial insurance
- covered with prior authorisation
Covered for FDA-labelled and NCCN-listed uses, but almost always behind prior authorisation confirming diagnosis, biomarker and line of therapy; dispensed through a specialty pharmacy.
- Assistance programmes
- BMS Access Support
- Bristol Myers Squibb Patient Assistance Foundation
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
- Leukemia & Lymphoma Society financial support
Part D out-of-pocket capped at $2,000 (2025) / $2,100 (2026). Medicare patients cannot use manufacturer co-pay cards; charity funds (PAN, HealthWell, CancerCare) and the Extra Help subsidy are the routes.
Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.
- Appraised for
- Myelofibrosis-related splenomegaly or symptoms after ruxolitinib
- NHS England
- Routinely funded for the appraised indication (or via managed access)
Sources: NICE TA756 · SMC advice: fedratinib. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2019 | Intermediate-2/high-risk primary or secondary myelofibrosis |
| EU | 2021 | Myelofibrosis, JAK-inhibitor-naive or after ruxolitinib |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Fedratinib" OR ABSTRACT:"Fedratinib" OR TITLE:"Inrebic" OR ABSTRACT:"Inrebic") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Fedratinib, not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductPacritinib
Shares COMFORT-I: ruxolitinib, the first JAK inhibitor, versus placebo for myelofibrosis, JAK2, FLT3, Myeloproliferative neoplasms (PV, ET, myelofibrosis) and the tag gap-fill.
- ProductMomelotinib
Shares COMFORT-I: ruxolitinib, the first JAK inhibitor, versus placebo for myelofibrosis, JAK2, Myeloproliferative neoplasms (PV, ET, myelofibrosis), Small-molecule kinase inhibitors and the tag gap-fill.
- ProductRopeginterferon alfa-2b
Shares JAK2, Myeloproliferative neoplasms (PV, ET, myelofibrosis) and the tag gap-fill.
- ProductRuxolitinib
Shares COMFORT-I: ruxolitinib, the first JAK inhibitor, versus placebo for myelofibrosis, JAK2, Myeloproliferative neoplasms (PV, ET, myelofibrosis), Small-molecule kinase inhibitors and the tag gap-fill.
- ProductLuspatercept
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Bristol Myers Squibb and the tag gap-fill.
- ProductRusfertide
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis) and the tag gap-fill.
- TargetMDM2
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Small-molecule kinase inhibitors and the tag gap-fill.
- ProductElotuzumab
Shares Bristol Myers Squibb and the tag gap-fill.