OnCo
drugsProductNot mapped hereapproved

Elotuzumab

An immune-stimulating antibody for myeloma that works only in combination, adding benefit to lenalidomide or pomalidomide.

ELOQUENT-2 (2015): PFS 19.4 vs 14.9 months with lenalidomide-dexamethasone; ELOQUENT-3 (2018) with pomalidomide-dexamethasone. Largely displaced by CD38 antibodies but remains an option in daratumumab-refractory disease.

Schematic of the modality · Anti-SLAMF7 monoclonal antibody · not a molecule; see the Monoclonal antibodies page
Modality
Anti-SLAMF7 monoclonal antibody
Mechanism
Binds SLAMF7 (CS1) on myeloma cells and NK cells, enhancing NK-mediated ADCC; no single-agent activity.
Brand / code
Empliciti
Medicare
Part B (clinician-administered)

Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies.

Commercial insurance
covered with prior authorisation

Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments.

20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.

Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.

Not yet researchedSearch NICE
Notes
Licensed 2016; NICE appraisal terminated or not recommended and elotuzumab is not routinely used on the NHS. Check NICE.

Sources: NICE search: elotuzumab. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.

Regulatory

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Approvals

RegionYearIndication
US2015Multiple myeloma after 1-3 prior therapies, with lenalidomide-dexamethasone
US2018With pomalidomide-dexamethasone after ≥2 therapies

Trials

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ClinicalTrials.gov · phase 2/3
refreshed 2026-09-09
56 studies7 recruiting40 Phase 216 Phase 3
Search “Elotuzumab” on ClinicalTrials.gov →
Counts are from a name search and may include unrelated studies; up to 100 studies are summarised.

Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
Elotuzumab
intervention: Elotuzumab
Open on ClinicalTrials.gov →

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Latest papers

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Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"Elotuzumab" OR ABSTRACT:"Elotuzumab" OR TITLE:"Empliciti" OR ABSTRACT:"Empliciti") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Elotuzumab, not a curated reading list.

Connected

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