Elotuzumab
An immune-stimulating antibody for myeloma that works only in combination, adding benefit to lenalidomide or pomalidomide.
ELOQUENT-2 (2015): PFS 19.4 vs 14.9 months with lenalidomide-dexamethasone; ELOQUENT-3 (2018) with pomalidomide-dexamethasone. Largely displaced by CD38 antibodies but remains an option in daratumumab-refractory disease.
- Medicare
- Part B (clinician-administered)
Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies.
- Commercial insurance
- covered with prior authorisation
Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments.
- Assistance programmes
- BMS Access Support
- Bristol Myers Squibb Patient Assistance Foundation
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
- Leukemia & Lymphoma Society financial support
20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.
- Notes
- Licensed 2016; NICE appraisal terminated or not recommended and elotuzumab is not routinely used on the NHS. Check NICE.
Sources: NICE search: elotuzumab. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2015 | Multiple myeloma after 1-3 prior therapies, with lenalidomide-dexamethasone |
| US | 2018 | With pomalidomide-dexamethasone after ≥2 therapies |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Elotuzumab" OR ABSTRACT:"Elotuzumab" OR TITLE:"Empliciti" OR ABSTRACT:"Empliciti") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Elotuzumab, not a curated reading list.
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