Linked human organ chips to predict side effects before people are dosed
Damage to the lungs, heart or liver is a common reason cancer drugs fail. Connected chips of human tissue may spot this earlier than animal tests.
Interstitial lung disease with ADCs, cardiotoxicity with HER2 agents and hepatotoxicity with several classes are poorly predicted by rodents. Coupled microphysiological systems with human lung, heart, liver and kidney compartments and shared circulation can measure organ-specific injury from a candidate at clinically relevant exposures. US legislation now allows non-animal methods to support investigational new drug applications, giving a regulatory route.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
- Toxicity and quality of life are undervalued · Trials measure how long people live, not how they live. Side-effects are under-reported and under-treated.
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not linked directly; found by shared links- IdeaTumour-on-a-chip with blood flow to test whether big drugs actually get in
Shares Payload (ADC), Patient-derived organoids, Preclinical models that do not predict people, Antibody-drug conjugate (ADC).
- IdeaDose and schedule optimisation trials specific to antibody-drug conjugates
Shares Interstitial lung disease (ILD) / pneumonitis, Payload (ADC), Toxicity and quality of life are undervalued, Antibody-drug conjugate (ADC).
- TermDuocarmycin (seco-DUBA)
- IdeaKeep a freshly removed tumour alive on a pump and test drugs in it
Shares Patient-derived organoids, Preclinical models that do not predict people.
- IdeaContinuous-flow synthesis of ultra-potent ADC payloads to ease the capacity squeeze
- IdeaBuild laboratory models of the organs cancer spreads to
Shares Patient-derived organoids, Preclinical models that do not predict people.
- IdeaTest flat versus weight-based dosing of antibodies, and use dose banding to cut waste
Shares Interstitial lung disease (ILD) / pneumonitis, Antibody-drug conjugate (ADC).
- TermDNA alkylator payloads