Keep a freshly removed tumour alive on a pump and test drugs in it
After surgery, a tumour with its blood vessels can be connected to a pump and kept alive for hours or days, allowing drugs to be tested in genuinely human tissue.
Normothermic machine perfusion is standard in transplantation for livers and kidneys and can be applied to resected tumour-bearing specimens (for example liver segments containing metastases, or isolated limb specimens). Perfusion preserves vasculature and interstitial transport, so drug delivery, penetration and early pharmacodynamics can be measured in intact human tissue that no model reproduces.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
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not linked directly; found by shared links- InstitutionAtrium Health Wake Forest Baptist Comprehensive Cancer Center
Shares Patient-derived organoids, Preclinical models that do not predict people, Colorectal cancer.
- IdeaBuild laboratory models of the organs cancer spreads to
Shares Patient-derived organoids, Preclinical models that do not predict people.
- CompanySirtex Medical
- IdeaAutomated combination discovery: patient-sample screens feeding Bayesian platform trials
Shares Patient-derived organoids, Preclinical models that do not predict people, Colorectal cancer.
- IdeaA bone marrow niche on a chip to study human dormancy
Shares Patient-derived organoids, Preclinical models that do not predict people.
- IdeaTest drugs on freshly cut slices of the patient's own tumour
Shares Patient-derived organoids, Preclinical models that do not predict people.
- IdeaBarcode patient-derived tumours to watch which clones win under each drug
Shares Patient-derived organoids, Preclinical models that do not predict people.
- IdeaLinked human organ chips to predict side effects before people are dosed
Shares Patient-derived organoids, Preclinical models that do not predict people.