Test drugs on freshly cut slices of the patient's own tumour
A thin slice of a tumour, kept alive for a few days, still contains the immune cells and scaffolding that lab-grown cells lose. Drugs can be tested on it directly.
Precision-cut tumour slices preserve native architecture, stroma, vasculature remnants and resident immune cells for several days, and have been used to measure responses to chemotherapy, targeted agents and immunotherapy with imaging and single-cell readouts. They avoid the selection and adaptation that occur during organoid derivation, at the cost of a short experimental window.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
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not linked directly; found by shared links- IdeaA bone marrow niche on a chip to study human dormancy
Shares Functional (ex vivo) drug testing, Single-cell & spatial profiling, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaHold organoid drug tests to the same standard as a diagnostic test
Shares Curesponse, Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaGrow each trial patient's tumour as organoids to decide which platform arm opens next
Shares Curesponse, Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- InstitutionAtrium Health Wake Forest Baptist Comprehensive Cancer Center
Shares Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaTest drugs on the patient's own cancer cells when there is no trial to join
Shares Curesponse, Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- TechnologyOrganoid-guided therapy at scale
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- IdeaGrow tumour organoids together with the patient's own immune cells
Shares Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaA drug screen that only rewards killing sleeping cancer cells
Shares Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.