Escrow a share of adult revenue until the paediatric study is done
Companies often delay the childhood cancer studies they are required to do. A slice of the adult drug's revenue would be held back until the paediatric trial is completed.
Under the US RACE for Children Act and EU Paediatric Regulation, companies must plan paediatric studies for molecularly relevant cancer drugs, but deferrals and waivers are common and completion lags years. A rule would place a small percentage (for example 2%) of adult sales into escrow from launch, released on completion of the agreed paediatric study or forfeited to a paediatric oncology trials fund after the deadline. This aligns commercial interest with timely paediatric evidence without new appropriations.
- Incentives reward me-too drugs and marginal gains · The system pays the same for a drug that adds two months as for a cure, so companies race to copy rather than to cure.
- Rare and paediatric cancers without markets · Taken together rare cancers are a fifth of all cancers, but each one alone is too small for a company to invest in.
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not linked directly; found by shared links- IdeaMake paediatric combination studies part of every relevant adult cancer drug approval
Shares Children's Oncology Group (COG), Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Acute lymphoblastic leukaemia.
- IdeaAn international consortium pooling the outcome of every treated child with cancer
Shares Children's Oncology Group (COG), Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- IdeaPay a prize for rare cancer drugs instead of hoping for a market
Shares Neuroblastoma (paediatric), Incentives reward me-too drugs and marginal gains, Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- IdeaOne global paediatric cancer development plan instead of separate FDA and EMA plans
Shares Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Acute lymphoblastic leukaemia.
- IdeaMilestone-based venture philanthropy with royalties recycled into the pipeline
Shares Advance market commitments for paediatric and rare cancer drugs, Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- IdeaGuaranteed-quality childhood cancer medicines free of charge in 50 countries
Shares Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Acute lymphoblastic leukaemia.
- InstitutionChildren's Cancer Hospital Egypt 57357
Shares Children's Oncology Group (COG), Neuroblastoma (paediatric), Sarcomas (soft tissue, bone, GIST), Acute lymphoblastic leukaemia.
- IdeaA paediatric palliative care team in every childhood cancer unit
Shares Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Acute lymphoblastic leukaemia.