Margetuximab
A trastuzumab look-alike with an engineered tail that binds immune cells more tightly; approved in 2020 but rarely used after ADCs arrived.
SOPHIA (vs trastuzumab, both with chemotherapy, after ≥2 anti-HER2 lines): PFS 5.8 vs 4.9 months (HR 0.76); OS not significantly improved, with a suggestion of benefit in CD16A-158F carriers. Approved December 2020. Illustrates the ceiling of Fc engineering alone versus payload delivery.
- Route
- Intravenous
- Schedule
- 15 mg/kg every 3 weeks with chemotherapy
- Medicare
- Part B (clinician-administered)
Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies.
- Commercial insurance
- covered with prior authorisation
Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments.
20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.
- Notes
- No UK marketing authorisation as of September 2026, so no NICE appraisal. Access only through a clinical trial or a company early access scheme.
- NHS England
- Not routinely funded
Sources: NICE search: margetuximab. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Compare all products across the US, EU, UK, Japan, China and Australia →
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2020 | HER2+ metastatic breast cancer after ≥2 anti-HER2 regimens, with chemotherapy |
| Adverse event | Any grade | Grade 3+ |
|---|---|---|
| Infusion-related reactions | 13% | — |
| Left ventricular dysfunction | 2% | — |
Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
Trials
topRecruiting now (live from ClinicalTrials.gov)
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Latest papers
topQuery for this drug: (TITLE:"Margetuximab" OR ABSTRACT:"Margetuximab" OR TITLE:"Margenza" OR ABSTRACT:"Margenza") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Margetuximab, not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductMogamulizumab
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies.
- TermNK cell
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies.
- InstitutionUniversity Hospital Southampton / Centre for Cancer Immunology
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies.
- ProductElotuzumab
Shares ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies.
- ProductTrastuzumab biosimilars
Shares Monoclonal antibodies, HER2, HER2-positive breast cancer.
- TargetCCR4
Shares ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies.
- TargetCD52
Shares ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies.
- PathwayComplement in cancer
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), NK-cell recognition: missing self & stress ligands, Monoclonal antibodies.