termsTerm
Fc engineering / effector function
Tweaking the antibody's tail to make it recruit immune cells more strongly, or not at all.
Afucosylation and Fc mutations enhance ADCC; Fc-silencing (IgG4, LALA mutations) prevents unwanted immune activation in checkpoint inhibitors and T-cell engagers. Half-life extension via FcRn-binding mutations.
Immunology: what this kind of term is about · animated schematic, not to scale
Category
Immunology