Antibody
A Y-shaped protein the immune system makes to grab onto one specific target. Manufactured antibodies are now a cornerstone of cancer treatment, either blocking a protein or delivering a payload to it.
Each antibody's two arm tips bind one specific antigen with great precision, while its stem (the Fc region) can recruit immune cells and complement or extend the antibody's life in the blood. Therapeutic antibodies block growth receptors (trastuzumab on HER2, cetuximab on EGFR), release the brakes on T cells (pembrolizumab on PD-1), flag cancer cells for immune killing (rituximab on CD20), or serve as the targeting vehicle of ADCs and radioimmunotherapy. Bispecific antibodies have two different arm tips and can physically pull a T cell onto a tumour cell.
Pages like this
not linked directly; found by shared links- TermT cell
Shares Epitope, NK cell, Immune system, Antigen.
- InstitutionUniversity Hospital Southampton / Centre for Cancer Immunology
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies, Immune checkpoint inhibitors.
- ProductMogamulizumab
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies.
- IdeaHome infusion and local blood draws for trial drugs after the first cycles
Shares Trastuzumab, Monoclonal antibodies, Pembrolizumab, Immune checkpoint inhibitors.
- ProductMargetuximab
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies.
- PathwayNK-cell recognition: missing self & stress ligands
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Bispecific antibodies, Trastuzumab.
- IdeaApprove cancer biosimilars on analytics and pharmacokinetics, no efficacy trials
Shares Trastuzumab, Monoclonal antibodies, Pembrolizumab.
- PathwayComplement in cancer
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies, Immune checkpoint inhibitors.