Vimseltinib
Vimseltinib is a pill approved in February 2025 for tenosynovial giant cell tumour, a benign but destructive joint tumour, offering an alternative to repeated surgery.
MOTION: ORR 40% vs 0% at week 25; improvements in range of motion, pain and function; no liver toxicity signal of the kind that limited pexidartinib. Approved 14 February 2025. Deciphera/Ono.
- Route
- Oral
- Schedule
- 30 mg twice weekly
- Monitoring
- Liver enzymes, CPK, cholesterol, periorbital oedema
- Medicare
- Part D (self-administered)
Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026). FDA-approved February 2025.
- Commercial insurance
- covered with prior authorisation
Covered for FDA-labelled and NCCN-listed uses, but almost always behind prior authorisation confirming diagnosis, biomarker and line of therapy; dispensed through a specialty pharmacy.
- Assistance programmes
- Deciphera AccessPoint
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
Part D out-of-pocket capped at $2,000 (2025) / $2,100 (2026). Medicare patients cannot use manufacturer co-pay cards; charity funds (PAN, HealthWell, CancerCare) and the Extra Help subsidy are the routes.
Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.
- Notes
- No UK marketing authorisation as of September 2026, so no NICE appraisal. Access only through a clinical trial or a company early access scheme.
- NHS England
- Not routinely funded
Sources: NICE search: vimseltinib. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Compare all products across the US, EU, UK, Japan, China and Australia →
- 14 Feb 2025ApprovalUS
MOTION source
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2025 | Symptomatic tenosynovial giant cell tumour where surgery would worsen function or cause severe morbidity |
| Adverse event | Any grade | Grade 3+ |
|---|---|---|
| Periorbital oedema | 45% | — |
| Fatigue | 33% | — |
| Increased CPK | 28% | — |
| Pruritus | 28% | — |
MOTION. Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
Trials
topRecruiting now (live from ClinicalTrials.gov)
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"Vimseltinib" OR ABSTRACT:"Vimseltinib" OR TITLE:"Romvimza" OR ABSTRACT:"Romvimza") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Vimseltinib, not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductPexidartinib
Shares CSF1R, Myeloid suppression: TAMs, MDSCs & don't-eat-me signals, Sarcomas (soft tissue, bone, GIST), Small-molecule kinase inhibitors.
- ProductRipretinib
Shares Deciphera Pharmaceuticals (Ono), Sarcomas (soft tissue, bone, GIST), Small-molecule kinase inhibitors.
- TargetPDGFRA
Shares CSF1R, Sarcomas (soft tissue, bone, GIST), Small-molecule kinase inhibitors.
- ProductPazopanib
Shares Sarcomas (soft tissue, bone, GIST), Small-molecule kinase inhibitors.
- ProductAvapritinib
Shares Sarcomas (soft tissue, bone, GIST), Small-molecule kinase inhibitors.
- CancerGastrointestinal stromal tumour (GIST)
Shares Deciphera Pharmaceuticals (Ono), Small-molecule kinase inhibitors.
- InstitutionCentre Léon Bérard
Shares Sarcomas (soft tissue, bone, GIST), Small-molecule kinase inhibitors.
- PathwayComplement in cancer
Shares CSF1R, Myeloid suppression: TAMs, MDSCs & don't-eat-me signals.