Humanised mice with an immune system matched to the tumour donor
Most cancer drugs are tested in mice with no immune system, then given to people who have one. Mice carrying the same patient's immune cells and tumour would be a fairer test.
Standard PDX models use immunodeficient mice, which cannot evaluate immunotherapy or immune-mediated toxicity. Humanised immune system mice reconstituted with HLA-matched or autologous haematopoietic cells, ideally with human cytokine knock-in backgrounds to support myeloid development, allow tumour and immune system from the same donor. Cost and reproducibility have kept them niche.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
- No one can predict who responds to immunotherapy · Checkpoint drugs cure some patients and do nothing for most. We still cannot tell the two apart before treating.
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not linked directly; found by shared links- IdeaRun the mouse or organoid trial at the same time as the human trial
Shares Champions Oncology, Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaMulti-laboratory preclinical trials as the standard for go/no-go decisions
Shares Champions Oncology, Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaZebrafish avatars for a drug answer within a week
Shares Patient-derived xenografts, Preclinical models that do not predict people.
- InstitutionThe Jackson Laboratory Cancer Center
Shares Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaPre-specified sample sizes for animal studies; no more 'representative' experiments
Shares Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaBuild laboratory models of the organs cancer spreads to
Shares Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaMake bespoke mouse cancer models in weeks with in vivo gene editing
Shares Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaTest cancer drugs in old and unhealthy animals, not just young fit ones
Shares Preclinical models that do not predict people, Immune checkpoint inhibitors.